Pabpc2 poly(A) binding protein, cytoplasmic 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pabpc2provided by MGI
Official Full Name: poly(A) binding protein, cytoplasmic 2provided by MGI
Primary source: MGI:MGI:1349723
See related: Ensembl:ENSMUSG00000051732 AllianceGenome:MGI:1349723
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pabp; Pabp+; Pabp2
Summary: Predicted to enable RNA binding activity and protein C-terminus binding activity. Predicted to act upstream of or within mRNA polyadenylation. Predicted to be located in cell leading edge and cytoplasmic ribonucleoprotein granule. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in brain and testis. Orthologous to several human genes including PABPC1 (poly(A) binding protein cytoplasmic 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 18 B3; 18 21.14 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (39906550..39909135)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (39773497..39776082)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of functional compensation for the loss of mouse PABPC2 in spermatogenic cells
Title: Functional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis.
PABPC2 was present in pachytene spermatocytes and round spermatids, whereas elongating spermatids still included PABPC1.
Title: Characterization of two cytoplasmic poly(A)-binding proteins, PABPC1 and PABPC2, in mouse spermatogenic cells.
Poly(A) binding protein (PABP) is identified as an Msi1-binding protein, and Msi1 competes with eIF4G for PABP binding.
Title: Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

mPabpc2 (e-PCR)
- UniSTS:514586

Pabpc1 (e-PCR), detects polymorphism
- UniSTS:265534

Pabpc1 (e-PCR), detects polymorphism
- UniSTS:265535

UniSTS:479186 (e-PCR)
- UniSTS:479186

Pabpc2 (e-PCR), detects polymorphism
- UniSTS:479186

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	TAS Traceable Author Statement more info	PubMed
enables poly(U) RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of mRNA 3'-end processing	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: poly A binding protein, cytoplasmic 2

Names: poly A binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.