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Oxtr oxytocin receptor [ Mus musculus (house mouse) ]

Gene ID: 18430, updated on 21-Apr-2024

Summary

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Official Symbol
Oxtrprovided by MGI
Official Full Name
oxytocin receptorprovided by MGI
Primary source
MGI:MGI:109147
See related
Ensembl:ENSMUSG00000049112 AllianceGenome:MGI:109147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OTR
Summary
Predicted to enable oxytocin receptor activity; peptide hormone binding activity; and vasopressin receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within positive regulation of blood pressure. Predicted to be located in adherens junction; apical plasma membrane; and microvillus. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adipose tissue; brain; genitourinary system; integumental system; and small intestine. Orthologous to human OXTR (oxytocin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 71.9), mammary gland adult (RPKM 22.4) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 E3; 6 52.27 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (112450646..112467800, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (112473683..112491035, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53304 Neighboring gene STARR-seq mESC enhancer starr_17017 Neighboring gene predicted gene, 35649 Neighboring gene caveolin 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:112497386-112497539 Neighboring gene predicted gene, 35706 Neighboring gene ADP-ribosylation factor GTPase activating protein 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Necessity of integrated genomic analysis to establish a designed knock-in mouse from CRISPR-Cas9-induced mutants. Yoshida M, et al. Sci Rep, 2022 Nov 27. PMID 36437283, Free PMC Article
  2. Oxytocin Receptors in the Mouse Centrally-projecting Edinger-Westphal Nucleus and their Potential Functional Significance for Thermoregulation. Li J, et al. Neuroscience, 2022 Aug 21. PMID 35803493, Free PMC Article
  3. Oxytocin suppresses epithelial cell-derived cytokines production and alleviates intestinal inflammation in food allergy. Yu Y, et al. Biochem Pharmacol, 2022 Jan. PMID 34863977
  4. Stress-related memories disrupt sociability and associated patterning of hippocampal activity: a role of hilar oxytocin receptor-positive interneurons. Meyer MAA, et al. Transl Psychiatry, 2020 Dec 12. PMID 33311459, Free PMC Article
  5. Voluntary alcohol consumption is increased in female, but not male, oxytocin receptor knockout mice. Rodriguez KM, et al. Brain Behav, 2020 Sep. PMID 32666677, Free PMC Article

See all (163) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oxytocin receptors in the prefrontal cortex play important roles in short-term social recognition in mice.
    Title: Oxytocin receptors in the prefrontal cortex play important roles in short-term social recognition in mice.
  2. Sexually dimorphic oxytocin receptor-expressing (OXTR) neurons in the anteroventral periventricular nucleus (AVPV) in the postpartum female mouse are involved in maternal behavior.
    Title: Sexually dimorphic oxytocin receptor-expressing (OXTR) neurons in the anteroventral periventricular nucleus (AVPV) in the postpartum female mouse are involved in maternal behavior.
  3. Local CRF and oxytocin receptors correlate with female experience-driven avoidance change and hippocampal neuronal plasticity.
    Title: Local CRF and oxytocin receptors correlate with female experience-driven avoidance change and hippocampal neuronal plasticity.
  4. Vasopressin receptor 1a, oxytocin receptor, and oxytocin knockout male and female mice display normal perceptual abilities towards non-social odorants.
    Title: Vasopressin receptor 1a, oxytocin receptor, and oxytocin knockout male and female mice display normal perceptual abilities towards non-social odorants.
  5. Analysis of the hypothalamic oxytocin system and oxytocin receptor-expressing astrocytes in a mouse model of Prader-Willi syndrome.
    Title: Analysis of the hypothalamic oxytocin system and oxytocin receptor-expressing astrocytes in a mouse model of Prader-Willi syndrome.
  6. Vasopressin V1a receptor and oxytocin receptor regulate murine sperm motility differently.
    Title: Vasopressin V1a receptor and oxytocin receptor regulate murine sperm motility differently.
  7. Oxytocin Receptors in the Mouse Centrally-projecting Edinger-Westphal Nucleus and their Potential Functional Significance for Thermoregulation.
    Title: Oxytocin Receptors in the Mouse Centrally-projecting Edinger-Westphal Nucleus and their Potential Functional Significance for Thermoregulation.
  8. Oxytocin via oxytocin receptor excites neurons in the endopiriform nucleus of juvenile mice.
    Title: Oxytocin via oxytocin receptor excites neurons in the endopiriform nucleus of juvenile mice.
  9. Oxytocin receptor is a potential biomarker of the hyporesponsive HPA axis subtype of PTSD and might be modulated by HPA axis reactivity traits in humans and mice.
    Title: Oxytocin receptor is a potential biomarker of the hyporesponsive HPA axis subtype of PTSD and might be modulated by HPA axis reactivity traits in humans and mice.
  10. Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.
    Title: Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.
Submit: New GeneRIF Correction See all GeneRIFs (80)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables oxytocin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxytocin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables vasopressin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maternal behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in maternal process involved in parturition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in memory ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of blood pressure IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of penile erection ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of uterine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vasoconstriction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of systemic arterial blood pressure by vasopressin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to amphetamine ISO
Inferred from Sequence Orthology
more info
  
involved_in response to anoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in response to steroid hormone ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in social behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in sperm ejaculation ISO
Inferred from Sequence Orthology
more info
  
involved_in suckling behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oxytocin receptor
Names
OT-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081147.3 → NP_001074616.1  oxytocin receptor isoform 1

    See identical proteins and their annotated locations for NP_001074616.1

    Status: VALIDATED

    Source sequence(s)
    AC153594
    Consensus CDS
    CCDS39588.1
    UniProtKB/Swiss-Prot
    F8VQ78, P97926
    UniProtKB/TrEMBL
    Q3UPP9
    Related
    ENSMUSP00000051132.7, ENSMUST00000053306.8
    Conserved Domains (1) summary
    cd15387
    Location:40 → 339
    7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001410246.1 → NP_001397175.1  oxytocin receptor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153594
    UniProtKB/TrEMBL
    A0A0N4SVY6
    Related
    ENSMUSP00000145300.2, ENSMUST00000204027.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    112450646..112467800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165923.1 → XP_036021816.1  oxytocin receptor isoform X1

    UniProtKB/Swiss-Prot
    F8VQ78, P97926
    UniProtKB/TrEMBL
    Q3UPP9
    Conserved Domains (1) summary
    cd15387
    Location:40 → 339
    7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97926.2 GenPept UniProtKB/Swiss-Prot:P97926

Gene LinkOut

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