Osmr oncostatin M receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Osmrprovided by MGI
Official Full Name: oncostatin M receptorprovided by MGI
Primary source: MGI:MGI:1330819
See related: Ensembl:ENSMUSG00000022146 AllianceGenome:MGI:1330819
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OSMRB
Summary: Enables cytokine binding activity and oncostatin-M receptor activity. Predicted to be involved in oncostatin-M-mediated signaling pathway and positive regulation of cell population proliferation. Predicted to act upstream of or within cell surface receptor signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; hemolymphoid system; lung; sensory organ; and skeletal system. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 1. Orthologous to human OSMR (oncostatin M receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 9.5), subcutaneous fat pad adult (RPKM 5.8) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 3.3 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (6843049..6904434, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (6813568..6874968, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling.
Title: OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling.
Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling.
Title: Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling.
Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis.
Title: Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis.
Murine Oncostatin M Has Opposing Effects on the Proliferation of OP9 Bone Marrow Stromal Cells and NIH/3T3 Fibroblasts Signaling through the OSMR.
Title: Murine Oncostatin M Has Opposing Effects on the Proliferation of OP9 Bone Marrow Stromal Cells and NIH/3T3 Fibroblasts Signaling through the OSMR.
OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation.
Title: OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation.
The results of the present study provide evidence that the overexpression of miR183 promotes the apoptosis of substantia nigra neurons by inhibiting the expression of OSMR.
Title: Overexpression of microRNA-183 promotes apoptosis of substantia nigra neurons via the inhibition of OSMR in a mouse model of Parkinson's disease.
The current study suggested that the OSMR gene is highly expressed in human chronic autoimmune urticaria (CAU) skin tissues, and cause the up-regulation of the JAK/STAT3 signaling pathway-related genes. OSMR gene silencing in mice inhibits the activation of the JAK/STAT3 signaling pathway, thereby suppressing the development of CAU.
Title: OSMR gene effect on the pathogenesis of chronic autoimmune Urticaria via the JAK/STAT3 pathway.
The results suggest that BRG1 and STAT3 coordinately regulate gene clustering and up-regulate Gfap and Osmr transcription in astrocytes.
Title: Gfap and Osmr regulation by BRG1 and STAT3 via interchromosomal gene clustering in astrocytes.
OSMR-beta deficiency in macrophages improved high-fat diet-induced atherogenesis and plaque vulnerability
Title: Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages.
Osmr expression in healthy mouse colon tissue was detected in endothelial and stromal cells. In agreement with observations of increased OSMR expression in inflamed colon tissue, the number of cells expressing Osmr was markedly increased in the lamina propria of mice with colitis.
Title: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF058805 (e-PCR)
- UniSTS:160436

Osmr (e-PCR), detects polymorphism
- UniSTS:502730

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ciliary neurotrophic factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables oncostatin-M receptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to oncostatin-M receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in oncostatin-M-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of oncostatin-M receptor complex	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: oncostatin-M-specific receptor subunit beta

Names: IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; interleukin-31 receptor subunit beta; oncostatin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310469.2 → NP_001297398.1 oncostatin-M-specific receptor subunit beta isoform 2 precursor

See identical proteins and their annotated locations for NP_001297398.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site in the 3' coding region compared to variant 1. The resulting isoform (2) is 1 amino acid shorter than isoform 1.

Source sequence(s)

AC102825, AC109183

Consensus CDS

CCDS79358.1

UniProtKB/Swiss-Prot

O70458, O88821

UniProtKB/TrEMBL

A0A0R4J268, B9EHD2

Related

ENSMUSP00000135204.2, ENSMUST00000176826.2

Conserved Domains (4) summary

smart00060
Location:437 → 512

FN3; Fibronectin type 3 domain

cd00063
Location:621 → 729

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:332 → 413

fn3; Fibronectin type III domain

cl21522
Location:230 → 289

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_011019.4 → NP_035149.2 oncostatin-M-specific receptor subunit beta isoform 1 precursor

See identical proteins and their annotated locations for NP_035149.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1)

Source sequence(s)

AC102825, AC109183

Consensus CDS

CCDS27368.1

UniProtKB/Swiss-Prot

O70458, O88821

UniProtKB/TrEMBL

B9EHD2, G3X8V6

Related

ENSMUSP00000022746.7, ENSMUST00000022746.13

Conserved Domains (4) summary

smart00060
Location:437 → 512

FN3; Fibronectin type 3 domain

cd00063
Location:622 → 730

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:30 → 137

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam00041
Location:332 → 413

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

6843049..6904434 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159232.1 → XP_036015125.1 oncostatin-M-specific receptor subunit beta isoform X1

UniProtKB/Swiss-Prot

O70458, O88821

UniProtKB/TrEMBL

B9EHD2, G3X8V6

Conserved Domains (4) summary

smart00060
Location:437 → 512

FN3; Fibronectin type 3 domain

cd00063
Location:622 → 730

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:30 → 137

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam00041
Location:332 → 413

fn3; Fibronectin type III domain
XM_006519973.5 → XP_006520036.1 oncostatin-M-specific receptor subunit beta isoform X1

See identical proteins and their annotated locations for XP_006520036.1

UniProtKB/Swiss-Prot

O70458, O88821

UniProtKB/TrEMBL

B9EHD2, G3X8V6

Conserved Domains (4) summary

smart00060
Location:437 → 512

FN3; Fibronectin type 3 domain

cd00063
Location:622 → 730

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:30 → 137

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam00041
Location:332 → 413

fn3; Fibronectin type III domain
XM_030248385.2 → XP_030104245.1 oncostatin-M-specific receptor subunit beta isoform X2

UniProtKB/TrEMBL

B9EHD2

Conserved Domains (3) summary

smart00060
Location:270 → 345

FN3; Fibronectin type 3 domain

cd00063
Location:455 → 563

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:63 → 122

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...