prp-4 Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: prp-4
Gene description: Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein
Primary source: WormBase:WBGene00007972
Locus tag: CELE_C36B1.5
See related: AllianceGenome:WB:WBGene00007972
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable U4 snRNA binding activity and U6 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nuclear speck. Predicted to be part of U4/U6 x U5 tri-snRNP complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 70. Orthologous to human PRPF4 (pre-mRNA processing factor 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (8733413..8735717, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C36B1.5 (e-PCR)
- UniSTS:309263

C36B1.7 (e-PCR)
- UniSTS:321973

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables U4 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U6 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of U4/U6 x U5 tri-snRNP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein

NP_492363.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8733413..8735717 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059962.4 → NP_492363.1 Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492363.1

Status: REVIEWED

UniProtKB/TrEMBL

Q93339

Conserved Domains (3) summary

smart00500
Location:76 → 115

SFM; Splicing Factor Motif, present in Prp18 and Pr04

cd00200
Location:191 → 492

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:207 → 244

7WD40; WD40 repeat [structural motif]