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unc-75 RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 182722, updated on 5-May-2024

Summary

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Gene symbol
unc-75
Gene description
RRM domain-containing protein
Primary source
WormBase:WBGene00006807
Locus tag
CELE_C17D12.2
See related
AllianceGenome:WB:WBGene00006807
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables single-stranded RNA binding activity. Involved in several processes, including cholinergic synaptic transmission; positive regulation of synaptic transmission; and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Is expressed in neurons and pharyngeal gland cell. Orthologous to several human genes including CELF5 (CUGBP Elav-like family member 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (11592246..11601712)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Sperm transmembrane protein 9 Neighboring gene UBC core domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PeriCentriolar MatriX Deficient Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans. Koterniak B, et al. Genome Res, 2020 Dec. PMID 33127752, Free PMC Article
  2. Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans. Kuroyanagi H, et al. Nucleic Acids Res, 2013 Apr. PMID 23416545, Free PMC Article
  3. A pair of RNA-binding proteins controls networks of splicing events contributing to specialization of neural cell types. Norris AD, et al. Mol Cell, 2014 Jun 19. PMID 24910101, Free PMC Article
  4. CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins. Chen L, et al. Elife, 2016 Jun 2. PMID 27253061, Free PMC Article
  5. CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans. Kuroyanagi H, et al. PLoS Genet, 2013. PMID 23468662, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans.
    Title: Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans.
  2. this study identifies two conserved RNA-binding proteins, UNC-75/CELF and EXC-7/Hu/ELAV, which regulate overlapping networks of splicing events in GABAergic and cholinergic neurons.
    Title: A pair of RNA-binding proteins controls networks of splicing events contributing to specialization of neural cell types.
  3. The results indicate that UNC-75 regulates alternative splicing of its target exons in neuron-specific and position-dependent manners through the (G/U)UGUUGUG elements in C. elegans.
    Title: Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans.
  4. Taken together, UNC-75 is the neuron-specific splicing factor and regulates both sets of the mutually exclusive exons of the unc-32 gene.
    Title: CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RRM domain-containing protein
NP_001300407.1
  • Confirmed by transcript evidence
NP_001300408.1
  • Confirmed by transcript evidence
NP_001300409.1
  • Partially confirmed by transcript evidence
NP_492958.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    11592246..11601712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060557.7 → NP_492958.3  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492958.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE68
    Conserved Domains (3) summary
    cd12632
    Location:24 → 110
    RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:425 → 503
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:123 → 203
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001313478.3 → NP_001300407.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AWH2
    Conserved Domains (2) summary
    cd12632
    Location:24 → 110
    RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:123 → 203
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001313479.3 → NP_001300408.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AR68
    Conserved Domains (2) summary
    cd12639
    Location:327 → 405
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:25 → 105
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. NM_001313480.3 → NP_001300409.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATM0
    Conserved Domains (1) summary
    cl17169
    Location:25 → 105
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
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