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mlst-8 Target of rapamycin complex subunit lst8 [ Caenorhabditis elegans ]

Gene ID: 182509, updated on 23-Nov-2023

Summary

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Gene symbol
mlst-8
Gene description
Target of rapamycin complex subunit lst8
Primary source
WormBase:WBGene00015697
Locus tag
CELE_C10H11.8
See related
AllianceGenome:WB:WBGene00015697
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in mesendoderm development. Predicted to be part of TORC1 complex and TORC2 complex. Orthologous to human MLST8 (MTOR associated protein, LST8 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (4735251..4738102, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene UDP-glucuronosyltransferase Neighboring gene glucuronosyltransferase Neighboring gene UDP-glucuronosyltransferase Neighboring gene Rho-associated protein kinase let-502 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. Jones KT, et al. PLoS Biol, 2009 Mar 3. PMID 19260765, Free PMC Article
  2. TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development. Ruf V, et al. Dev Biol, 2013 Dec 15. PMID 23973804, Free PMC Article
  3. A shift of the TOR adaptor from Rictor towards Raptor by semaphorin in C. elegans. Nukazuka A, et al. Nat Commun, 2011 Sep 27. PMID 21952218, Free PMC Article
  4. TOR and ageing: a complex pathway for a complex process. McCormick MA, et al. Philos Trans R Soc Lond B Biol Sci, 2011 Jan 12. PMID 21115526, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mesendoderm development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of TORC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of TORC1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
  
part_of TORC2 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Target of rapamycin complex subunit lst8
NP_001249708.1
  • Confirmed by transcript evidence
NP_001249709.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4735251..4738102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001262780.3 → NP_001249709.1  Target of rapamycin complex subunit lst8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001249709.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91040
    Conserved Domains (2) summary
    sd00039
    Location:46 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:46 → 353
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001262779.3 → NP_001249708.1  Target of rapamycin complex subunit lst8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001249708.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E5QCF5
    Conserved Domains (2) summary
    sd00039
    Location:20 → 53
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:20 → 327
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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