Nr4a2 nuclear receptor subfamily 4, group A, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nr4a2provided by MGI
Official Full Name: nuclear receptor subfamily 4, group A, member 2provided by MGI
Primary source: MGI:MGI:1352456
See related: Ensembl:ENSMUSG00000026826 AllianceGenome:MGI:1352456
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NOT; HZF-3; Nurr1; RNR-1; TINOR; TINUR
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; glucocorticoid receptor binding activity; and protein heterodimerization activity. Involved in several processes, including cellular response to corticotropin-releasing hormone stimulus; dopaminergic neuron differentiation; and fat cell differentiation. Acts upstream of or within several processes, including dopamine biosynthetic process; nervous system development; and response to amphetamine. Located in nucleus. Is expressed in several structures, including alimentary system; ear; genitourinary system; integumental system; and nervous system. Used to study Parkinson's disease and schizophrenia. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human NR4A2 (nuclear receptor subfamily 4 group A member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 2.3), stomach adult (RPKM 2.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.1; 2 31.66 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (56996845..57014152, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (57106830..57124003, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NR4a1/2 deletion promotes accumulation of TCF1[+] stem-like precursors of exhausted CD8[+] T cells in the tumor microenvironment.
Title: NR4a1/2 deletion promotes accumulation of TCF1(+) stem-like precursors of exhausted CD8(+) T cells in the tumor microenvironment.
Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex.
Title: Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex.
Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation.
Title: Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation.
Prolonged cardiac NR4A2 activation causes dilated cardiomyopathy in mice.
Title: Prolonged cardiac NR4A2 activation causes dilated cardiomyopathy in mice.
Nurr1 Is Not an Essential Regulator of BDNF in Mouse Cortical Neurons.
Title: Nurr1 Is Not an Essential Regulator of BDNF in Mouse Cortical Neurons.
Nurr1 repression mediates cardinal features of Parkinson's disease in alpha-synuclein transgenic mice.
Title: Nurr1 repression mediates cardinal features of Parkinson's disease in α-synuclein transgenic mice.
Nurr1 deficiency shortens free running period, enhances photoentrainment to phase advance, and disrupts circadian cycling of the dopamine neuron phenotype.
Title: Nurr1 deficiency shortens free running period, enhances photoentrainment to phase advance, and disrupts circadian cycling of the dopamine neuron phenotype.
Aberrant mTOR/autophagy/Nurr1 signaling is critical for TSC-associated tumor development.
Title: Aberrant mTOR/autophagy/Nurr1 signaling is critical for TSC-associated tumor development.
Nurr1 downregulation is caused by CREB inactivation in a Parkinson's disease mouse model.
Title: Nurr1 downregulation is caused by CREB inactivation in a Parkinson's disease mouse model.
Nurr1(Cd11bcre) conditional knockout mice display inflammatory injury to nigrostriatal dopaminergic neurons.
Title: Nurr1(Cd11bcre) conditional knockout mice display inflammatory injury to nigrostriatal dopaminergic neurons.

Submit: New GeneRIF Correction See all GeneRIFs (110)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nr4a2 (e-PCR), detects polymorphism
- UniSTS:507412

PMC109903P2 (e-PCR)
- UniSTS:270181

D3Wox30 (e-PCR)
- UniSTS:240527

Nr4a2 (e-PCR), detects polymorphism
- UniSTS:536540

Nr4a2 (e-PCR), detects polymorphism
- UniSTS:546539

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear glucocorticoid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear glucocorticoid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to corticotropin-releasing hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to corticotropin-releasing hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system projection neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dopamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopaminergic neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in dopaminergic neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopaminergic neuron differentiation	TAS Traceable Author Statement more info	PubMed
involved_in fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within general adaptation syndrome	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within habenula development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of catalytic activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of dopamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of respiratory gaseous exchange	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to inorganic substance	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within response to insecticide	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nuclear receptor subfamily 4 group A member 2

Names: NUR-related factor 1; nur related protein 1; orphan nuclear receptor NURR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001139509.2 → NP_001132981.1 nuclear receptor subfamily 4 group A member 2 isoform a

See identical proteins and their annotated locations for NP_001132981.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1 and encodes isoform a. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AL844871

Consensus CDS

CCDS16043.1

UniProtKB/Swiss-Prot

O08690, Q06219

UniProtKB/TrEMBL

Q3TYI4

Related

ENSMUSP00000108248.2, ENSMUST00000112629.8

Conserved Domains (2) summary

cd07071
Location:361 → 598

NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:261 → 335

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
NM_001420480.1 → NP_001407409.1 nuclear receptor subfamily 4 group A member 2 isoform a

Status: VALIDATED

Source sequence(s)

AL844871

UniProtKB/Swiss-Prot

O08690, Q06219

UniProtKB/TrEMBL

Q3TYI4
NM_001420481.1 → NP_001407410.1 nuclear receptor subfamily 4 group A member 2 isoform b

Status: VALIDATED

Source sequence(s)

AL844871

UniProtKB/TrEMBL

A2AQQ8
NM_001420482.1 → NP_001407411.1 nuclear receptor subfamily 4 group A member 2 isoform b

Status: VALIDATED

Source sequence(s)

AL844871

UniProtKB/TrEMBL

A2AQQ8
NM_013613.3 → NP_038641.1 nuclear receptor subfamily 4 group A member 2 isoform a

See identical proteins and their annotated locations for NP_038641.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AL844871

Consensus CDS

CCDS16043.1

UniProtKB/Swiss-Prot

O08690, Q06219

UniProtKB/TrEMBL

Q3TYI4

Related

ENSMUSP00000028166.3, ENSMUST00000028166.9

Conserved Domains (2) summary

cd07071
Location:361 → 598

NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:261 → 335

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

RNA

NR_185185.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL844871
NR_185186.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL844871
NR_185187.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL844871

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

56996845..57014152 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159386.1 → XP_036015279.1 nuclear receptor subfamily 4 group A member 2 isoform X1

UniProtKB/Swiss-Prot

O08690, Q06219

UniProtKB/TrEMBL

Q3TYI4

Conserved Domains (2) summary

cd07071
Location:361 → 598

NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:261 → 335

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
XM_011239033.4 → XP_011237335.1 nuclear receptor subfamily 4 group A member 2 isoform X1

See identical proteins and their annotated locations for XP_011237335.1

UniProtKB/Swiss-Prot

O08690, Q06219

UniProtKB/TrEMBL

Q3TYI4

Conserved Domains (2) summary

cd07071
Location:361 → 598

NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:261 → 335

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B