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Nras neuroblastoma ras oncogene [ Mus musculus (house mouse) ]

Gene ID: 18176, updated on 21-Apr-2024

Summary

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Official Symbol
Nrasprovided by MGI
Official Full Name
neuroblastoma ras oncogeneprovided by MGI
Primary source
MGI:MGI:97376
See related
Ensembl:ENSMUSG00000027852 AllianceGenome:MGI:97376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N-ras
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in positive regulation of angiogenesis. Acts upstream of or within several processes, including T cell receptor signaling pathway; defense response to protozoan; and positive regulation of interferon-gamma production. Located in membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 24.4), placenta adult (RPKM 18.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.2; 3 45.25 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (102965643..102975230)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (103058285..103067914)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4568 Neighboring gene suppressor of IKBKE 1 Neighboring gene STARR-seq mESC enhancer starr_08583 Neighboring gene cold shock domain containing E1, RNA binding Neighboring gene STARR-seq mESC enhancer starr_08584 Neighboring gene STARR-seq mESC enhancer starr_08585 Neighboring gene adenosine monophosphate deaminase 1 Neighboring gene STARR-seq mESC enhancer starr_08586 Neighboring gene DENN domain containing 2C Neighboring gene STARR-seq mESC enhancer starr_08590 Neighboring gene STARR-seq mESC enhancer starr_08592

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation. Murphy BM, et al. Nat Commun, 2022 Jun 7. PMID 35672316, Free PMC Article
  2. Oncogenic N-Ras Mitigates Oxidative Stress-Induced Apoptosis of Hematopoietic Stem Cells. Ney GM, et al. Cancer Res, 2021 Mar 1. PMID 33441311, Free PMC Article
  3. Senescent bone marrow microenvironment promotes Nras-mutant leukemia. Zhou P, et al. J Mol Cell Biol, 2021 Apr 10. PMID 33196790, Free PMC Article
  4. Aspirin Protects Melanocytes and Keratinocytes against UVB-Induced DNA Damage In Vivo. Rahman H, et al. J Invest Dermatol, 2021 Jan. PMID 32569596
  5. Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Zambetti NA, et al. Blood, 2020 May 14. PMID 32219446, Free PMC Article

See all (209) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice.
    Title: A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice.
  2. RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
    Title: RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
  3. Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis.
    Title: Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis.
  4. Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras(Q61R/+) mice.
    Title: Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras(Q61R/+) mice.
  5. Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation.
    Title: Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation.
  6. Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation.
    Title: Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation.
  7. Senescent bone marrow microenvironment promotes Nras-mutant leukemia.
    Title: Senescent bone marrow microenvironment promotes Nras-mutant leukemia.
  8. Oncogenic NRAS Accelerates Rhabdomyosarcoma Formation When Occurring within a Specific Time Frame during Tumor Development in Mice.
    Title: Oncogenic NRAS Accelerates Rhabdomyosarcoma Formation When Occurring within a Specific Time Frame during Tumor Development in Mice.
  9. Targeted Therapy Given after Anti-PD-1 Leads to Prolonged Responses in Mouse Melanoma Models through Sustained Antitumor Immunity.
    Title: Targeted Therapy Given after Anti-PD-1 Leads to Prolonged Responses in Mouse Melanoma Models through Sustained Antitumor Immunity.
  10. Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors.
    Title: Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors.
Submit: New GeneRIF Correction See all GeneRIFs (77)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Ras protein signal transduction TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of skeletal muscle tissue development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of skeletal muscle tissue development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell cycle TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
GTPase NRas
Names
transforming protein N-Ras
NP_001355567.1
NP_001397438.1
NP_001397439.1
NP_001397440.1
NP_001397441.1
NP_001397442.1
NP_035067.2
XP_006501183.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368638.2 → NP_001355567.1  GTPase NRas

    Status: VALIDATED

    Source sequence(s)
    AC163297
    Consensus CDS
    CCDS38570.1
    UniProtKB/TrEMBL
    Q3TMF4, Q3UCX0, Q9D091
    Related
    ENSMUSP00000143391.2, ENSMUST00000200069.5
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  2. NM_001410509.1 → NP_001397438.1  GTPase NRas

    Status: VALIDATED

    Source sequence(s)
    AC163297
    UniProtKB/TrEMBL
    Q9D091

  3. NM_001410510.1 → NP_001397439.1  GTPase NRas

    Status: VALIDATED

    Source sequence(s)
    AC163297
    UniProtKB/TrEMBL
    Q9D091

  4. NM_001410511.1 → NP_001397440.1  GTPase NRas

    Status: VALIDATED

    Source sequence(s)
    AC163297
    UniProtKB/TrEMBL
    Q9D091
    Related
    ENSMUSP00000143644.2, ENSMUST00000199049.5

  5. NM_001410512.1 → NP_001397441.1  GTPase NRas

    Status: VALIDATED

    Source sequence(s)
    AC163297
    UniProtKB/TrEMBL
    Q9D091

  6. NM_001410513.1 → NP_001397442.1  GTPase NRas

    Status: VALIDATED

    Source sequence(s)
    AC163297
    UniProtKB/TrEMBL
    Q9D091
    Related
    ENSMUSP00000142438.2, ENSMUST00000196355.5

  7. NM_010937.3 → NP_035067.2  GTPase NRas

    See identical proteins and their annotated locations for NP_035067.2

    Status: VALIDATED

    Source sequence(s)
    AC163297
    Consensus CDS
    CCDS38570.1
    UniProtKB/TrEMBL
    Q3TMF4, Q3UCX0, Q9D091
    Related
    ENSMUSP00000029445.7, ENSMUST00000029445.13
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

RNA

  1. NR_177084.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163297
    Related
    ENSMUST00000128264.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    102965643..102975230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501120.5 → XP_006501183.1  GTPase NRas isoform X2

    See identical proteins and their annotated locations for XP_006501183.1

    UniProtKB/TrEMBL
    Q3TMF4, Q3UCX0, Q9D091
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08556.1 GenPept UniProtKB/Swiss-Prot:P08556

Gene LinkOut

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