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F43B10.1 EF-hand domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181721, updated on 23-Nov-2023

Summary

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Gene symbol
F43B10.1
Gene description
EF-hand domain-containing protein
Primary source
WormBase:WBGene00018373
Locus tag
CELE_F43B10.1
See related
AllianceGenome:WB:WBGene00018373
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in protein dephosphorylation. Predicted to be part of protein phosphatase type 2A complex. Is expressed in body wall musculature; non-striated muscle; pharynx; and seam cell. Orthologous to several human genes including PPP2R3A (protein phosphatase 2 regulatory subunit B''alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
18
Sequence:
Chromosome: X; NC_003284.9 (16637633..16662823, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Lipid-binding serum glycoprotein C-terminal domain-containing protein Neighboring gene tRNA-His Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA polymerase II-associated factor 1 homolog Neighboring gene Spore coat protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A. Anders KR, et al. EMBO J, 2003 Feb 3. PMID 12554664, Free PMC Article
  2. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article
  3. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that the role of SMG-5 is to direct protein phosphatase 2A to its SMG-2 substrate
    Title: SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
EF-hand domain-containing protein
NP_001257276.1
  • Confirmed by transcript evidence
NP_001257277.1
  • Confirmed by transcript evidence
NP_001335559.1
  • Partially confirmed by transcript evidence
NP_001335569.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    16637633..16662823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348608.3 → NP_001335559.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYT5
    Conserved Domains (2) summary
    pfam13499
    Location:467 → 566
    EF-hand_7; EF-hand domain pair
    cl26464
    Location:153 → 308
    Atrophin-1; Atrophin-1 family

  2. NM_001348609.4 → NP_001335569.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYW5
    Conserved Domains (2) summary
    pfam13499
    Location:1096 → 1195
    EF-hand_7; EF-hand domain pair
    cl26464
    Location:473 → 937
    Atrophin-1; Atrophin-1 family

  3. NM_001270348.4 → NP_001257277.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257277.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17744
    Conserved Domains (1) summary
    pfam13499
    Location:331 → 427
    EF-hand_7; EF-hand domain pair

  4. NM_001270347.4 → NP_001257276.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257276.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H8W3X6
    Conserved Domains (1) summary
    pfam13499
    Location:379 → 475
    EF-hand_7; EF-hand domain pair
Nucleotide Protein
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