ace-1 Acetylcholinesterase 1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: ace-1
Gene description: Acetylcholinesterase 1
Primary source: WormBase:WBGene00000035
Locus tag: CELE_W09B12.1
See related: AllianceGenome:WB:WBGene00000035
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables acetylcholinesterase activity and identical protein binding activity. Involved in acetylcholine catabolic process and regulation of locomotion. Located in extracellular space. Is expressed in M cell; body wall musculature; head neurons; and non-striated muscle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; coronary artery disease (multiple); diabetes mellitus (multiple); epilepsy; and myasthenia gravis. Orthologous to human ACHE (acetylcholinesterase (Cartwright blood group)) and BCHE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ace-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (16367293..16373789)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACE-1 is an amphiphilic tetramer associated with a hydrophobic non-catalytic subunit, analogous to vertebrate T enzymes, whereas ACE-2 and ACE-3 are glycosylphosphatidylinositol-linked amphiphilic dimers
Title: Nematode acetylcholinesterases are encoded by multiple genes and perform non-overlapping functions.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W09B12.1 (e-PCR)
- UniSTS:315197

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acetylcholinesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholinesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholinesterase activity	IEA Inferred from Electronic Annotation more info
enables acetylcholinesterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables cholinesterase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acetylcholine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetylcholine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acetylcholine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acetylcholine catabolic process in synaptic cleft	IC Inferred by Curator more info	PubMed
involved_in choline metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic cleft	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Acetylcholinesterase 1

NP_510660.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

16367293..16373789

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078259.9 → NP_510660.1 Acetylcholinesterase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510660.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P38433

Conserved Domains (2) summary

COG0657
Location:114 → 249

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam00135
Location:13 → 561

COesterase; Carboxylesterase family