B0395.3 Choline/carnitine acyltransferase domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: B0395.3
Gene description: Choline/carnitine acyltransferase domain-containing protein
Primary source: WormBase:WBGene00007175
Locus tag: CELE_B0395.3
See related: AllianceGenome:WB:WBGene00007175
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable carnitine O-acetyltransferase activity. Predicted to be involved in carnitine metabolic process, CoA-linked. Predicted to be active in peroxisome. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human CRAT (carnitine O-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See B0395.3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 11

Sequence:: Chromosome: X; NC_003284.9 (16035036..16039231, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of L-carnitine as a neuromodulator and antiaging medication.
Title: Carnitine: a neuromodulator in aged rats.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0395.3 (e-PCR)
- UniSTS:313401

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables carnitine O-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carnitine metabolic process, CoA-linked	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Choline/carnitine acyltransferase domain-containing protein

NP_510624.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

16035036..16039231 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078223.8 → NP_510624.1 Choline/carnitine acyltransferase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510624.1

Status: REVIEWED

UniProtKB/TrEMBL

Q17499

Conserved Domains (1) summary

pfam00755
Location:22 → 601

Carn_acyltransf; Choline/Carnitine o-acyltransferase