Nppb natriuretic peptide type B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nppbprovided by MGI
Official Full Name: natriuretic peptide type Bprovided by MGI
Primary source: MGI:MGI:97368
See related: Ensembl:ENSMUSG00000029019 AllianceGenome:MGI:97368
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BNF; BNP; Iso-ANP
Summary: This gene encodes a secreted protein that belongs to the family of natriuretic peptides. Its precursor protein is processed to generate the active mature peptide. The mature peptide is a cardiac hormone that plays a role in ventricular remodeling as well as blood pressure regulation. Mice lacking this gene exhibit cardiac fibrosis. In humans this gene is associated with congestive heart failure, low bone-mineral density and postmenopausal osteoporosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
Expression: Restricted expression toward heart adult (RPKM 51.3) See more
Orthologs: human all
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Genomic context

Location:: 4 E1; 4 78.57 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (148070264..148071662)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (147985786..147987205)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of Fap Promotes Cardiac Repair by Stabilizing BNP.
Title: Inhibition of Fap Promotes Cardiac Repair by Stabilizing BNP.
Cardiac natriuretic peptide deficiency sensitizes the heart to stress-induced ventricular arrhythmias via impaired CREB signalling.
Title: Cardiac natriuretic peptide deficiency sensitizes the heart to stress-induced ventricular arrhythmias via impaired CREB signalling.
BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk.
Title: BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk.
Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart.
Title: Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart.
Atopic dermatitis linked cytokine interleukin-31 induced itch is mediated via a NPPB pathway.
Title: Atopic Dermatitis Linked Cytokine Interleukin-31 Induced Itch Mediated via a Neuropeptide Natriuretic Polypeptide B.
These results suggested that the papillary tip express a substance that can stimulate BNP production and secretion from cardiomyocytes.
Title: Renal papillary tip extract stimulates BNP production and excretion from cardiomyocytes.
This study provides the first evidence of the ability of IL-18 to induce B-type natriuretic peptide synthesis in vitro and outlines the relationship between the two molecules in acute HF patients with an ongoing inflammatory status.
Title: IL-18 stimulates B-type natriuretic peptide synthesis by cardiomyocytes in vitro and its plasma levels correlate with B-type natriuretic peptide in non-overloaded acute heart failure patients.
The present study provides a novel insight into the potential underlying mechanisms of telmisartan-induced inhibition of cardiomyocyte hypertrophy, which involves inhibition of NFAT activation, nuclear translocation and the ANP/BNP cascade.
Title: Telmisartan suppresses cardiac hypertrophy by inhibiting cardiomyocyte apoptosis via the NFAT/ANP/BNP signaling pathway.
the developmental regulation and stress response of the Nppa-Nppb cluster involve the concerted action of multiple enhancers and epigenetic changes distributed across a structurally rigid regulatory domain.
Title: Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress.
Data suggest that the negative inhibition of P2X3R activity by the BNP/NPR-A pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.
Title: Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (7) 1 citation

General gene information

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Markers

Nppb (e-PCR), detects polymorphism
- UniSTS:144058

RH124694 (e-PCR)
- UniSTS:161516

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cGMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in coronary vasculature development	IDA Inferred from Direct Assay more info	PubMed
involved_in endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in homeostasis of number of cells	IDA Inferred from Direct Assay more info	PubMed
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholangiocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collecting lymphatic vessel constriction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor guanylyl cyclase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxygen levels	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: natriuretic peptides B

Names: brain natriuretic factor prohormone; brain natriuretic peptide; gamma-brain natriuretic peptide; natriuretic peptide precursor type B; preproBNP; proBNP; type-B natriuretic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001287348.2 → NP_001274277.1 natriuretic peptides B isoform 2 preproprotein

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded protein (isoform 2, also known as Short isoform) is shorter than isoform 1.

Source sequence(s)

AL714013

UniProtKB/TrEMBL

O55086

Conserved Domains (1) summary

pfam00212
Location:84 → 114

ANP; Atrial natriuretic peptide
NM_008726.6 → NP_032752.1 natriuretic peptides B isoform 1 preproprotein

See identical proteins and their annotated locations for NP_032752.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as Long isoform).

Source sequence(s)

AL714013

Consensus CDS

CCDS18926.1

UniProtKB/Swiss-Prot

P40753

UniProtKB/TrEMBL

O55086, Q54AE9

Related

ENSMUSP00000099521.5, ENSMUST00000103231.5

Conserved Domains (1) summary

pfam00212
Location:85 → 115

ANP; Atrial natriuretic peptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

148070264..148071662

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538627.5 → XP_006538690.1 natriuretic peptides B isoform X1

UniProtKB/TrEMBL

O55086

Conserved Domains (1) summary

pfam00212
Location:85 → 115

ANP; Atrial natriuretic peptide