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acs-17 AMP-binding domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180859, updated on 23-Nov-2023

Summary

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Gene symbol
acs-17
Gene description
AMP-binding domain-containing protein
Primary source
WormBase:WBGene00016716
Locus tag
CELE_C46F4.2
See related
AllianceGenome:WB:WBGene00016716
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA metabolic process; and neuron differentiation. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum; lipid droplet; and plasma membrane. Human ortholog(s) of this gene implicated in asthma; breast cancer; intellectual disability; non-syndromic X-linked intellectual disability 63; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3) and ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (5937558..5944499, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene EB domain-containing protein Neighboring gene Nucleoside-diphosphatase mig-23 Neighboring gene VWFA domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. IRE-1 and HSP-4 contribute to energy homeostasis via fasting-induced lipases in C. elegans. Jo H, et al. Cell Metab, 2009 May. PMID 19416714
  2. Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Castelein N, et al. Biotechnol J, 2008 Jun. PMID 18383023
  3. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Tischler J, et al. Genome Biol, 2006. PMID 16884526, Free PMC Article
  4. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Murphy CT, et al. Nature, 2003 Jul 17. PMID 12845331
  5. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
AMP-binding domain-containing protein
NP_001360705.1
  • Partially confirmed by transcript evidence
NP_508993.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5937558..5944499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373312.4 → NP_001360705.1  AMP-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0ING4
    Conserved Domains (1) summary
    cd17639
    Location:133 → 708
    LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

  2. NM_076592.10 → NP_508993.2  AMP-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508993.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18660
    Conserved Domains (2) summary
    cd05927
    Location:133 → 717
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:78 → 717
    PLN02387; long-chain-fatty-acid-CoA ligase family protein
Nucleotide Protein
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