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cka-2 Choline kinase A2 [ Caenorhabditis elegans ]

Gene ID: 180703, updated on 23-Nov-2023

Summary

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Gene symbol
cka-2
Gene description
Choline kinase A2
Primary source
WormBase:WBGene00000510
Locus tag
CELE_C52B9.1
See related
AllianceGenome:WB:WBGene00000510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables choline kinase activity. Involved in CDP-choline pathway. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to human CHKA (choline kinase alpha) and CHKB (choline kinase beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (4286843..4291496)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ETS domain-containing protein Neighboring gene ncRNA Neighboring gene ETS class transcription factor Neighboring gene Platelet-activating factor acetylhydrolase homolog 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of critical residues of choline kinase A2 from Caenorhabditis elegans. Yuan C, et al. J Biol Chem, 2004 Apr 23. PMID 14960577
  2. Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization. Gee P, et al. Biochim Biophys Acta, 2003 May 30. PMID 12758145
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study of critical residues of choline kinase A2
    Title: Identification of critical residues of choline kinase A2 from Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables choline kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables choline kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ethanolamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ethanolamine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-choline pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CDP-choline pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylethanolamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Choline kinase A2
NP_001024480.1
  • Confirmed by transcript evidence
NP_001024481.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4286843..4291496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029309.6 → NP_001024480.1  Choline kinase A2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024480.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22942, Q2XN11
    Conserved Domains (1) summary
    cd05156
    Location:76 → 420
    ChoK_euk; Euykaryotic Choline Kinase

  2. NM_001029310.7 → NP_001024481.1  Choline kinase A2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024481.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22942
    Conserved Domains (2) summary
    PLN02236
    Location:43 → 401
    PLN02236; choline kinase
    cd05156
    Location:55 → 399
    ChoK_euk; Euykaryotic Choline Kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
1NW1_A.1
1NW1_B.1
Q22942.2

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