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Ngfr nerve growth factor receptor (TNFR superfamily, member 16) [ Mus musculus (house mouse) ]

Gene ID: 18053, updated on 4-Jan-2025

Summary

Official Symbol
Ngfrprovided by MGI
Official Full Name
nerve growth factor receptor (TNFR superfamily, member 16)provided by MGI
Primary source
MGI:MGI:97323
See related
Ensembl:ENSMUSG00000000120 AllianceGenome:MGI:97323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p75; LNGFR; p75NTR; p75NGFR; Tnfrsf16
Summary
Enables death receptor activity; nerve growth factor binding activity; and small GTPase binding activity. Involved in several processes, including circadian regulation of gene expression; dorsal aorta development; and intracellular glucose homeostasis. Acts upstream of or within several processes, including hair follicle morphogenesis; nervous system development; and regulation of signal transduction. Located in several cellular components, including cell surface; cell-cell junction; and postsynaptic density. Is active in neuromuscular junction. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease and depressive disorder. Orthologous to human NGFR (nerve growth factor receptor). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 31.4), ovary adult (RPKM 24.6) and 20 other tissues See more
Orthologs
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Genomic context

See Ngfr in Genome Data Viewer
Location:
11 D; 11 59.01 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95459644..95478524, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95568818..95587698, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53646 Neighboring gene STARR-positive B cell enhancer ABC_E9841 Neighboring gene neurexophilin 3 Neighboring gene STARR-seq mESC enhancer starr_30513 Neighboring gene STARR-positive B cell enhancer ABC_E304 Neighboring gene prohibitin 1 Neighboring gene predicted gene, 29873

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (11)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding  
enables calmodulin binding  
enables calmodulin binding  
enables coreceptor activity  
enables coreceptor activity  
enables coreceptor activity  
enables death receptor activity  
enables death receptor activity PubMed 
enables death receptor activity  
enables identical protein binding  
enables nerve growth factor binding  
enables nerve growth factor binding PubMed 
enables nerve growth factor binding  
enables neurotrophin TRKA receptor binding  
enables neurotrophin binding  
enables preprotein binding  
enables protein binding PubMed 
enables protein-containing complex binding  
enables small GTPase binding PubMed 
enables ubiquitin protein ligase binding  
enables ubiquitin protein ligase binding  
Items 1 - 25 of 59
Process Evidence Code Pubs
involved_in Rho protein signal transduction  
involved_in Rho protein signal transduction  
involved_in Rho protein signal transduction  
acts_upstream_of_or_within axon guidance PubMed 
involved_in cellular response to amyloid-beta  
involved_in cellular response to amyloid-beta  
involved_in cellular response to oxidative stress  
acts_upstream_of_or_within central nervous system development PubMed 
involved_in circadian regulation of gene expression PubMed 
involved_in circadian rhythm PubMed 
acts_upstream_of_or_within detection of temperature stimulus PubMed 
involved_in dorsal aorta development PubMed 
acts_upstream_of fibroblast growth factor receptor signaling pathway PubMed 
acts_upstream_of fibroblast proliferation PubMed 
involved_in glucose homeostasis PubMed 
acts_upstream_of hair follicle development PubMed 
acts_upstream_of_or_within hair follicle morphogenesis PubMed 
involved_in intracellular glucose homeostasis PubMed 
involved_in intracellular protein transport PubMed 
involved_in negative regulation of angiogenesis  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  
involved_in negative regulation of cell migration  
involved_in negative regulation of cell migration  
involved_in negative regulation of dendritic spine development  
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway PubMed 
acts_upstream_of_or_within negative regulation of hair follicle development PubMed 
involved_in negative regulation of mitochondrial depolarization  
involved_in negative regulation of neuron apoptotic process  
involved_in negative regulation of neuron projection development  
acts_upstream_of_or_within nerve development PubMed 
involved_in neuron apoptotic process  
involved_in neuron apoptotic process  
acts_upstream_of odontogenesis of dentin-containing tooth PubMed 
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of Rho protein signal transduction  
involved_in positive regulation of apoptotic process  
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity  
involved_in positive regulation of excitatory postsynaptic potential  
acts_upstream_of_or_within positive regulation of fibroblast proliferation PubMed 
involved_in positive regulation of miRNA transcription  
involved_in positive regulation of miRNA transcription  
involved_in positive regulation of myelination  
involved_in positive regulation of neural precursor cell proliferation  
involved_in positive regulation of neuron differentiation  
involved_in positive regulation of neuron projection development  
acts_upstream_of_or_within positive regulation of odontogenesis of dentin-containing tooth PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of protein localization to nucleus  
involved_in positive regulation of protein localization to nucleus  
involved_in positive regulation of synaptic transmission, cholinergic  
involved_in positive regulation of synaptic transmission, glutamatergic  
involved_in presynaptic modulation of chemical synaptic transmission PubMed 
involved_in presynaptic modulation of chemical synaptic transmission PubMed 
acts_upstream_of_or_within regulation of gene expression PubMed 
involved_in regulation of reactive oxygen species metabolic process  
acts_upstream_of_or_within skin development PubMed 
Items 1 - 25 of 59
Items 1 - 20 of 27
Component Evidence Code Pubs
is_active_in cell surface  
located_in cell surface PubMed 
located_in cell-cell junction PubMed 
located_in clathrin-coated endocytic vesicle  
located_in cytoplasm PubMed 
located_in dendrite membrane  
located_in dendritic spine  
located_in external side of plasma membrane  
located_in growth cone  
located_in mitochondrion  
is_active_in neuromuscular junction PubMed 
is_active_in neuromuscular junction PubMed 
is_active_in neuromuscular junction  
located_in neuronal cell body membrane  
located_in nuclear envelope  
located_in nucleoplasm  
located_in nucleoplasm  
located_in perikaryon  
located_in perikaryon  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in postsynaptic density PubMed 
located_in presynapse  
is_active_in presynaptic membrane  
Items 1 - 20 of 27

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 16
Names
NGF receptor
low affinity neurotrophin receptor p75NTR
low-affinity nerve growth factor receptor
low-affinity nerve growth factor receptor p75NGFR
low-affinity nerve growth factor receptor p75NGR
p75 neurotrophin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033217.3NP_150086.2  tumor necrosis factor receptor superfamily member 16 precursor

    See identical proteins and their annotated locations for NP_150086.2

    Status: VALIDATED

    Source sequence(s)
    AL662875
    Consensus CDS
    CCDS25279.1
    UniProtKB/Swiss-Prot
    Q8CFT3, Q9Z0W1
    UniProtKB/TrEMBL
    Q8BYY1
    Related
    ENSMUSP00000000122.7, ENSMUST00000000122.7
    Conserved Domains (3) summary
    cd08311
    Location:343418
    Death_p75NR; Death domain of p75 Neurotrophin Receptor
    cd13416
    Location:33191
    TNFRSF16; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271
    pfam18422
    Location:249286
    TNFR_16_TM; Tumor necrosis factor receptor member 16 trans-membrane domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    95459644..95478524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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