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DPEP1 dipeptidase 1 [ Homo sapiens (human) ]

Gene ID: 1800, updated on 3-Apr-2024

Summary

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Official Symbol
DPEP1provided by HGNC
Official Full Name
dipeptidase 1provided by HGNC
Primary source
HGNC:HGNC:3002
See related
Ensembl:ENSG00000015413 MIM:179780; AllianceGenome:HGNC:3002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDP; RDP; MBD1
Summary
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. [provided by RefSeq, Dec 2020]
Expression
Biased expression in small intestine (RPKM 104.6), kidney (RPKM 102.2) and 3 other tissues See more
Orthologs
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Genomic context

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See DPEP1 in Genome Data Viewer
Location:
16q24.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (89613308..89641540)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (95694848..95725329)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89679716..89707948)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89630776-89631518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89631519-89632262 Neighboring gene small nucleolar RNA, C/D box 68 Neighboring gene ribosomal protein L13 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:89640372-89640629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7916 Neighboring gene copine 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89665942-89666855 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:89679650-89679808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89681214-89681918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89681919-89682621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89689900-89690772 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89698470-89699324 Neighboring gene uncharacterized LOC124903758 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_46628 and experimental_46635 Neighboring gene charged multivesicular body protein 1A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7918 Neighboring gene spermatogenesis associated 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DPEP1 promotes drug resistance in colon cancer cells by forming a positive feedback loop with ASCL2. Zeng C, et al. Cancer Med, 2023 Jan. PMID 35670012, Free PMC Article
  2. The relationship between common variants in the DPEP1 gene and the susceptibility and clinical severity of osteoarthritis. Zhang Z, et al. Int J Rheum Dis, 2021 Sep. PMID 34291562
  3. DPEP1 expression promotes proliferation and survival of leukaemia cells and correlates with relapse in adults with common B cell acute lymphoblastic leukaemia. Zhang JM, et al. Br J Haematol, 2020 Jul. PMID 32068254
  4. Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer. Park SY, et al. Oncotarget, 2016 Feb 23. PMID 26824987, Free PMC Article
  5. Reintroduction of a Homocysteine Level-Associated Allele into East Asians by Neanderthal Introgression. Hu Y, et al. Mol Biol Evol, 2015 Dec. PMID 26392408

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DPEP1 promotes drug resistance in colon cancer cells by forming a positive feedback loop with ASCL2.
    Title: DPEP1 promotes drug resistance in colon cancer cells by forming a positive feedback loop with ASCL2.
  2. The relationship between common variants in the DPEP1 gene and the susceptibility and clinical severity of osteoarthritis.
    Title: The relationship between common variants in the DPEP1 gene and the susceptibility and clinical severity of osteoarthritis.
  3. A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
    Title: A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
  4. DPEP1 expression promotes proliferation and survival of leukaemia cells and correlates with relapse in adults with common B cell acute lymphoblastic leukaemia.
    Title: DPEP1 expression promotes proliferation and survival of leukaemia cells and correlates with relapse in adults with common B cell acute lymphoblastic leukaemia.
  5. DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway.
    Title: DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway.
  6. The results suggest that DPEP1 promotes cancer metastasis by regulating E-cadherin plasticity and that it might be a potential therapeutic target for preventing the progression of colon cancer.
    Title: Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer.
  7. In this study, we present an analysis of Neanderthal introgression at the dipeptidase 1 gene, DPEP1.
    Title: Reintroduction of a Homocysteine Level-Associated Allele into East Asians by Neanderthal Introgression.
  8. Dipeptidase 1 has been identified as an excellent marker of high-grade IEN and CRC, and may thus be applied for screening of early neoplastic lesions and for prognostic stratification.
    Title: Dipeptidase 1 (DPEP1) is a marker for the transition from low-grade to high-grade intraepithelial neoplasia and an adverse prognostic factor in colorectal cancer.
  9. DPEP1 plays a role in pancreatic cancer aggressiveness.
    Title: DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma.
  10. DPEP1 is expressed in the early stages of colon carcinogenesis and affects cancer cell invasiveness.
    Title: DPEP1, expressed in the early stages of colon carcinogenesis, affects cancer cell invasiveness.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GPI anchor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables beta-lactamase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables dipeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metallodipeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloexopeptidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables modified amino acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in antibiotic metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to nitric oxide ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutathione catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glutathione metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in homocysteine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in lactam catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in leukotriene D4 catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dipeptidase 1
Names
beta-lactamase
dehydropeptidase-I
dipeptidase 1 (renal)
hRDP
microsomal dipeptidase
renal dipeptidase
testicular tissue protein Li 57
NP_001121613.1
NP_001376395.1
NP_001376396.1
NP_001376397.1
NP_001376398.1
NP_001376399.1
NP_001376400.1
NP_004404.1
XP_024305941.1
XP_047289646.1
XP_047289647.1
XP_047289649.1
XP_054235704.1
XP_054235705.1
XP_054235706.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128141.3 → NP_001121613.1  dipeptidase 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001121613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3-6, encodes isoform a.
    Source sequence(s)
    AC010538, BC017023, BM152944
    Consensus CDS
    CCDS10982.1
    UniProtKB/Swiss-Prot
    D3DX80, P16444, Q96AK2
    UniProtKB/TrEMBL
    A0A140VJI3, Q6I9V1
    Related
    ENSP00000397313.1, ENST00000421184.5
    Conserved Domains (1) summary
    pfam01244
    Location:26 → 352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  2. NM_001389466.1 → NP_001376395.1  dipeptidase 1 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 2, and 4-6, encodes isoform a.
    Source sequence(s)
    AC010538
    Consensus CDS
    CCDS10982.1
    UniProtKB/Swiss-Prot
    D3DX80, P16444, Q96AK2
    UniProtKB/TrEMBL
    A0A140VJI3, Q6I9V1
    Related
    ENSP00000508584.1, ENST00000690203.1
    Conserved Domains (1) summary
    pfam01244
    Location:26 → 352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  3. NM_001389467.1 → NP_001376396.1  dipeptidase 1 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1-3, 5, and 6, encodes isoform a.
    Source sequence(s)
    AC010538
    Consensus CDS
    CCDS10982.1
    UniProtKB/Swiss-Prot
    D3DX80, P16444, Q96AK2
    UniProtKB/TrEMBL
    A0A140VJI3, Q6I9V1
    Conserved Domains (1) summary
    pfam01244
    Location:26 → 352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  4. NM_001389468.1 → NP_001376397.1  dipeptidase 1 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1-4 and 6, encodes isoform a.
    Source sequence(s)
    AC010538
    Consensus CDS
    CCDS10982.1
    UniProtKB/Swiss-Prot
    D3DX80, P16444, Q96AK2
    UniProtKB/TrEMBL
    A0A140VJI3, Q6I9V1
    Conserved Domains (1) summary
    pfam01244
    Location:26 → 352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  5. NM_001389469.1 → NP_001376398.1  dipeptidase 1 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1-5, encodes isoform a.
    Source sequence(s)
    AC010538, BC017023
    Consensus CDS
    CCDS10982.1
    UniProtKB/Swiss-Prot
    D3DX80, P16444, Q96AK2
    UniProtKB/TrEMBL
    A0A140VJI3, Q6I9V1
    Related
    ENSP00000261615.4, ENST00000261615.5
    Conserved Domains (1) summary
    pfam01244
    Location:26 → 352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  6. NM_001389470.1 → NP_001376399.1  dipeptidase 1 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 8, encodes isoform b.
    Source sequence(s)
    AC010538
    UniProtKB/TrEMBL
    Q6I9V1
    Conserved Domains (1) summary
    pfam01244
    Location:26 → 352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  7. NM_001389471.1 → NP_001376400.1  dipeptidase 1 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 7, encodes isoform b.
    Source sequence(s)
    AC010538
    UniProtKB/TrEMBL
    Q6I9V1
    Conserved Domains (1) summary
    pfam01244
    Location:26 → 352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  8. NM_004413.4 → NP_004404.1  dipeptidase 1 isoform a precursor

    See identical proteins and their annotated locations for NP_004404.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 2-6, encodes isoform a.
    Source sequence(s)
    AC010538, BC017023, J05257
    Consensus CDS
    CCDS10982.1
    UniProtKB/Swiss-Prot
    D3DX80, P16444, Q96AK2
    UniProtKB/TrEMBL
    A0A140VJI3, Q6I9V1
    Related
    ENSP00000376807.3, ENST00000393092.7
    Conserved Domains (1) summary
    pfam01244
    Location:26 → 352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    89613308..89641540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433691.1 → XP_047289647.1  dipeptidase 1 isoform X2

  2. XM_047433690.1 → XP_047289646.1  dipeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DX80, P16444, Q96AK2
    UniProtKB/TrEMBL
    A0A140VJI3

  3. XM_047433693.1 → XP_047289649.1  dipeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DX80, P16444, Q96AK2
    UniProtKB/TrEMBL
    A0A140VJI3

  4. XM_024450173.2 → XP_024305941.1  dipeptidase 1 isoform X3

    UniProtKB/TrEMBL
    Q6I9V1
    Conserved Domains (1) summary
    pfam01244
    Location:5 → 307
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    95694848..95725329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379729.1 → XP_054235704.1  dipeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DX80, P16444, Q96AK2
    UniProtKB/TrEMBL
    A0A140VJI3

  2. XM_054379730.1 → XP_054235705.1  dipeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DX80, P16444, Q96AK2
    UniProtKB/TrEMBL
    A0A140VJI3

  3. XM_054379731.1 → XP_054235706.1  dipeptidase 1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16444.3 GenPept UniProtKB/Swiss-Prot:P16444

Gene LinkOut

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