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rpt-1 26S proteasome regulatory subunit 7 [ Caenorhabditis elegans ]

Gene ID: 179641, updated on 5-May-2024

Summary

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Gene symbol
rpt-1
Gene description
26S proteasome regulatory subunit 7
Primary source
WormBase:WBGene00004501
Locus tag
CELE_C52E4.4
See related
AllianceGenome:WB:WBGene00004501
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Orthologous to human PSMC2 (proteasome 26S subunit, ATPase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See rpt-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (11980534..11982397, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mannosyl-oligosaccharide 1,2-alpha-mannosidase C52E4.5 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Symmetrically dividing cell specific division axes alteration observed in proteasome depleted C. elegans embryo. Sugiyama Y, et al. Mech Dev, 2008 Aug. PMID 18502617
  2. A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans. Martinez BA, et al. Cell Death Dis, 2015 Oct 15. PMID 26469957, Free PMC Article
  3. Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation. Howard RA, et al. BMC Cell Biol, 2007 Jul 30. PMID 17663792, Free PMC Article
  4. Evidence of glutathione transferase complexing and signaling in the model nematode Caenorhabditis elegans using a pull-down proteomic assay. Greetham D, et al. Proteomics, 2004 Jul. PMID 15221760
  5. A protein-protein interaction map of the Caenorhabditis elegans 26S proteasome. Davy A, et al. EMBO Rep, 2001 Sep. PMID 11559592, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables proteasome-activating activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome-activating activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome regulatory subunit 7
NP_506005.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11980534..11982397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073604.8 → NP_506005.1  26S proteasome regulatory subunit 7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506005.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18787
    Conserved Domains (2) summary
    COG1222
    Location:29 → 432
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
    pfam00004
    Location:214 → 345
    AAA; ATPase family associated with various cellular activities (AAA)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18787.1

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