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gly-20 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [ Caenorhabditis elegans ]

Gene ID: 179562, updated on 23-Nov-2023

Summary

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Gene symbol
gly-20
Gene description
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Primary source
WormBase:WBGene00001645
Locus tag
CELE_C03E10.4
See related
AllianceGenome:WB:WBGene00001645
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. Involved in protein N-linked glycosylation. Predicted to be located in Golgi stack and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIa. Orthologous to human MGAT2 (alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (11282572..11286039)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G protein-coupled receptor Neighboring gene ncRNA Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SweetBac: a new approach for the production of mammalianised glycoproteins in insect cells. Palmberger D, et al. PLoS One, 2012. PMID 22485160, Free PMC Article
  2. Mitochondrial complex I function affects halothane sensitivity in Caenorhabditis elegans. Kayser EB, et al. Anesthesiology, 2004 Aug. PMID 15277919
  3. Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1. Kayser EB, et al. J Biol Chem, 2004 Dec 24. PMID 15269213
  4. Alternative polyadenylation results in a truncated daf-4 BMP receptor that antagonizes DAF-7-mediated development in Caenorhabditis elegans. Gunther CV, et al. J Biol Chem, 2004 Sep 17. PMID 15254038
  5. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I and UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II in Caenorhabditis elegans. Chen S, et al. Biochim Biophys Acta, 2002 Dec 19. PMID 12417409

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in oligosaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NP_505864.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11282572..11286039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073463.9 → NP_505864.1  Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505864.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17560, Q9NGK7
    Conserved Domains (1) summary
    pfam05060
    Location:101 → 447
    MGAT2; N-acetylglucosaminyltransferase II (MGAT2)
Nucleotide Protein
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