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ugt-17 glucuronosyltransferase [ Caenorhabditis elegans ]

Gene ID: 179406, updated on 23-Nov-2023

Summary

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Gene symbol
ugt-17
Gene description
glucuronosyltransferase
Primary source
WormBase:WBGene00007422
Locus tag
CELE_C08B6.1
See related
AllianceGenome:WB:WBGene00007422
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (10102592..10104964, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Purple acid phosphatase Neighboring gene DUF19 domain-containing protein;PIR Superfamily Protein Neighboring gene Uncharacterized protein Neighboring gene Glycosyltransferase family 92 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alternative chaperone machinery may compensate for calreticulin/calnexin deficiency in Caenorhabditis elegans. Lee W, et al. Proteomics, 2006 Feb. PMID 16404716
  2. UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences. Matoušková P, et al. Int J Parasitol Drugs Drug Resist, 2018 Dec. PMID 30293057, Free PMC Article
  3. Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans. Lewis JA, et al. BMC Genomics, 2009 Apr 29. PMID 19402892, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucuronosyltransferase
NP_001122841.1
  • Confirmed by transcript evidence
NP_505597.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10102592..10104964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073196.8 → NP_505597.2  glucuronosyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505597.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17813
    Conserved Domains (1) summary
    cd03784
    Location:21 → 469
    GT1_Gtf-like; UDP-glycosyltransferases and similar proteins

  2. NM_001129369.6 → NP_001122841.1  glucuronosyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122841.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5JYT6
    Conserved Domains (2) summary
    PHA03392
    Location:1 → 513
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:22 → 538
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
Nucleotide Protein
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