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eif-2Bdelta Translation initiation factor eIF-2B subunit delta [ Caenorhabditis elegans ]

Gene ID: 179331, updated on 5-May-2024

Summary

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Gene symbol
eif-2Bdelta
Gene description
Translation initiation factor eIF-2B subunit delta
Primary source
WormBase:WBGene00008670
Locus tag
CELE_F11A3.2
See related
AllianceGenome:WB:WBGene00008670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable translation initiation factor activity. Involved in several processes, including determination of adult lifespan; lipid storage; and response to heat. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (9513824..9517649)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene CPG4 domain-containing protein Neighboring gene pseudo Neighboring gene Cocaine- and amphetamine-regulated transcript protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inhibition of a eukaryotic initiation factor (eIF2Bdelta/F11A3.2) during adulthood extends lifespan in Caenorhabditis elegans. Tohyama D, et al. FASEB J, 2008 Dec. PMID 18728216
  2. SKIP and BIR-1/Survivin have potential to integrate proteome status with gene expression. Kostrouch D, et al. J Proteomics, 2014 Oct 14. PMID 25088050
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Translation initiation factor eIF-2B subunit delta
NP_001023784.1
  • Confirmed by transcript evidence
NP_001023785.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9513824..9517649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028613.3 → NP_001023784.1  Translation initiation factor eIF-2B subunit delta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023784.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFF9
    Conserved Domains (1) summary
    cl00348
    Location:227 → 521
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]

  2. NM_001028614.6 → NP_001023785.1  Translation initiation factor eIF-2B subunit delta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023785.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG28
    Conserved Domains (1) summary
    cl00348
    Location:195 → 489
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
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