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Ppp1r12a protein phosphatase 1, regulatory subunit 12A [ Mus musculus (house mouse) ]

Gene ID: 17931, updated on 11-Apr-2024

Summary

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Official Symbol
Ppp1r12aprovided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 12Aprovided by MGI
Primary source
MGI:MGI:1309528
See related
Ensembl:ENSMUSG00000019907 AllianceGenome:MGI:1309528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mypt1; D10Ertd625e; 1200015F06Rik; 5730577I22Rik
Summary
Predicted to enable several functions, including 14-3-3 protein binding activity; phosphatase regulator activity; and protein kinase binding activity. Acts upstream of or within cellular response to xenobiotic stimulus; protein dephosphorylation; and regulation of nucleocytoplasmic transport. Located in A band and Z disc. Is expressed in corpus striatum; genital tubercle epithelium; head mesenchyme; urethra epithelium; and urothelium. Orthologous to human PPP1R12A (protein phosphatase 1 regulatory subunit 12A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 144.2), CNS E11.5 (RPKM 14.0) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp1r12a in Genome Data Viewer
Location:
10 D1; 10 56.33 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (107997913..108115846)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (108162092..108279985)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27787 Neighboring gene otogelin-like Neighboring gene predicted gene, 29685 Neighboring gene STARR-seq mESC enhancer starr_27789 Neighboring gene STARR-positive B cell enhancer ABC_E11458 Neighboring gene STARR-seq mESC enhancer starr_27796 Neighboring gene STARR-seq mESC enhancer starr_27797 Neighboring gene STARR-seq mESC enhancer starr_27798 Neighboring gene STARR-seq mESC enhancer starr_27807 Neighboring gene STARR-seq mESC enhancer starr_27810 Neighboring gene STARR-seq mESC enhancer starr_27812 Neighboring gene PRKC, apoptosis, WT1, regulator Neighboring gene predicted gene, 23105 Neighboring gene predicted gene, 36283 Neighboring gene predicted gene, 36440

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis. Takahashi H, et al. Nat Commun, 2022 Sep 29. PMID 36175407, Free PMC Article
  2. Editing of the myosin phosphatase regulatory subunit suppresses angiotensin II induced hypertension via sensitization to nitric oxide mediated vasodilation. Htet M, et al. Pflugers Arch, 2021 Apr. PMID 33145641
  3. Augmented contractility of murine femoral arteries in a streptozotocin diabetes model is related to increased phosphorylation of MYPT1. Lubomirov LT, et al. Physiol Rep, 2019 Feb. PMID 30740930, Free PMC Article
  4. The involvement of phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) and MYPT1 isoform expression in NO/cGMP mediated differential vasoregulation of cerebral arteries compared to systemic arteries. Lubomirov LT, et al. Acta Physiol (Oxf), 2018 Sep. PMID 29694711
  5. Localized Myosin II Activity Regulates Assembly and Plasticity of the Axon Initial Segment. Berger SL, et al. Neuron, 2018 Feb 7. PMID 29395909, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MYPT1-PP1beta phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis.
    Title: MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis.
  2. MYPT1 reduction is a pathogenic factor of erectile dysfunction.
    Title: MYPT1 reduction is a pathogenic factor of erectile dysfunction.
  3. Tissue-specific expression of myosin phosphatase subunits and isoforms in smooth muscle of mice and humans.
    Title: Tissue-specific expression of myosin phosphatase subunits and isoforms in smooth muscle of mice and humans.
  4. Editing of the myosin phosphatase regulatory subunit suppresses angiotensin II induced hypertension via sensitization to nitric oxide mediated vasodilation.
    Title: Editing of the myosin phosphatase regulatory subunit suppresses angiotensin II induced hypertension via sensitization to nitric oxide mediated vasodilation.
  5. O-GlcNAc modification of MYPT1 modulates lysophosphatidic acid-induced cell contraction in fibroblasts.
    Title: O-GlcNAc modification of MYPT1 modulates lysophosphatidic acid-induced cell contraction in fibroblasts.
  6. MYPT1 Down-regulation by Lipopolysaccharide-SIAH1/2 E3 Ligase-Ubiquitin-Proteasomal Degradation Contributes to Colonic Obstruction of Hirschsprung Disease.
    Title: MYPT1 Down-regulation by Lipopolysaccharide-SIAH1/2 E3 Ligase-Ubiquitin-Proteasomal Degradation Contributes to Colonic Obstruction of Hirschsprung Disease.
  7. Augmented contractility of murine femoral arteries in a streptozotocin diabetes model is related to increased threonine phosphorylation of MYPT1.
    Title: Augmented contractility of murine femoral arteries in a streptozotocin diabetes model is related to increased phosphorylation of MYPT1.
  8. The present results suggested that ROCK1 inhibitor could attenuate mechanical stretchinduced lung endothelial injury and the phosphorylation of MYPT1 in vivo and in vitro. Collectively, the present findings indicated that upregulation of SPHK1 may contribute to VALI in a twohit model.
    Title: Upregulation of sphingosine kinase 1 contributes to ventilator-associated lung injury in a two-hit model.
  9. findings reveal a role of Cx40 in regulation of ROCK1 and MLC20 that contributes critically to lung vascular barrier failure in acute lung injury.
    Title: Connexin 40 regulates lung endothelial permeability in acute lung injury via the ROCK1-MYPT1- MLC20 pathway.
  10. Phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) and MYPT1 isoform expression differentially regulates tone via NO/cGMP signaling in cerebral arteries compared to femoral arteries.
    Title: The involvement of phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) and MYPT1 isoform expression in NO/cGMP mediated differential vasoregulation of cerebral arteries compared to systemic arteries.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC159084

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myosin-light-chain-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of myosin-light-chain-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of myosin-light-chain-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in A band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in A band IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PTW/PP1 phosphatase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in contractile muscle fiber ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 12A
Names
myosin phosphatase target subunit 1
myosin phosphatase-targeting subunit 1
protein phosphatase 1, regulatory (inhibitor) subunit 12A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368736.1 → NP_001355665.1  protein phosphatase 1 regulatory subunit 12A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC139335
    Consensus CDS
    CCDS88083.1
    UniProtKB/Swiss-Prot
    Q05A74, Q8CBV2, Q99NB6, Q9DBR7
    Related
    ENSMUSP00000151842.2, ENSMUST00000219263.2
    Conserved Domains (4) summary
    PHA03095
    Location:43 → 272
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:47 → 136
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:930 → 1028
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  2. NM_001368737.1 → NP_001355666.1  protein phosphatase 1 regulatory subunit 12A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC139335
    Conserved Domains (4) summary
    PHA03095
    Location:43 → 272
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:47 → 136
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:874 → 972
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  3. NM_027892.3 → NP_082168.1  protein phosphatase 1 regulatory subunit 12A isoform 2

    See identical proteins and their annotated locations for NP_082168.1

    Status: VALIDATED

    Source sequence(s)
    AC139335
    Consensus CDS
    CCDS36052.1
    UniProtKB/Swiss-Prot
    Q9DBR7
    Related
    ENSMUSP00000069257.6, ENSMUST00000070663.6
    Conserved Domains (5) summary
    cd00204
    Location:67 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47 → 136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199 → 252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:930 → 984
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    107997913..108115846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513329.5 → XP_006513392.1  protein phosphatase 1 regulatory subunit 12A isoform X2

    See identical proteins and their annotated locations for XP_006513392.1

    Conserved Domains (3) summary
    PHA03095
    Location:43 → 272
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]
    pfam15898
    Location:873 → 971
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  2. XM_006513327.5 → XP_006513390.1  protein phosphatase 1 regulatory subunit 12A isoform X1

    Conserved Domains (3) summary
    PHA03095
    Location:43 → 272
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]
    pfam15898
    Location:930 → 984
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBR7.2 GenPept UniProtKB/Swiss-Prot:Q9DBR7

Gene LinkOut

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