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DOCK1 dedicator of cytokinesis 1 [ Homo sapiens (human) ]

Gene ID: 1793, updated on 3-Apr-2024

Summary

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Official Symbol
DOCK1provided by HGNC
Official Full Name
dedicator of cytokinesis 1provided by HGNC
Primary source
HGNC:HGNC:2987
See related
Ensembl:ENSG00000150760 MIM:601403; AllianceGenome:HGNC:2987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ced5; DOCK180
Summary
This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in thyroid (RPKM 10.9), skin (RPKM 10.0) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See DOCK1 in Genome Data Viewer
Location:
10q26.2
Exon count:
60
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (126905428..127452516)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (127789114..128347493)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (128593997..129250780)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD60 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:128581076-128581576 Neighboring gene uncharacterized LOC105378550 Neighboring gene uncharacterized LOC124900289 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:128595018-128595766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:128599458-128599958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:128599959-128600459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:128608337-128608885 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:128798279-128799478 Neighboring gene uncharacterized LOC107984059 Neighboring gene uncharacterized LOC105378552 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:128868600-128869799 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:128936224-128937423 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:128946487-128947686 Neighboring gene inhibitory synaptic factor 2A Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:129078632-129079159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4196 Neighboring gene uncharacterized LOC105378551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129190073-129190574 Neighboring gene uncharacterized LOC124902524 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:129262060-129262560 Neighboring gene neuropeptide S Neighboring gene forkhead box I2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TBOPP enhances the anticancer effect of cisplatin by inhibiting DOCK1 in renal cell carcinoma. Zhang W, et al. Mol Med Rep, 2020 Aug. PMID 32626999, Free PMC Article
  2. Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. McDonald MN, et al. J Cachexia Sarcopenia Muscle, 2017 Jun. PMID 28044437, Free PMC Article
  3. CRK SH3N Domain Diminishes Cell Invasiveness of Non-Small Cell Lung Cancer. Pezeshkpour GH, et al. Genes Cancer, 2013 Jul. PMID 24167658, Free PMC Article
  4. Solution structure of the SH3 domain of DOCK180. Liu X, et al. Proteins, 2013 May. PMID 23239367
  5. Overexpression of dedicator of cytokinesis I (Dock180) in ovarian cancer correlated with aggressive phenotype and poor patient survival. Zhao F, et al. Histopathology, 2011 Dec. PMID 22175896

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ESRP1 controls biogenesis and function of a large abundant multiexon circRNA.
    Title: ESRP1 controls biogenesis and function of a large abundant multiexon circRNA.
  2. DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway.
    Title: DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway.
  3. CircDOCK1 promotes the tumorigenesis and cisplatin resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis.
    Title: CircDOCK1 promotes the tumorigenesis and cisplatin resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis.
  4. LINC00665 promotes the progression of acute myeloid leukemia by regulating the miR-4458/DOCK1 pathway.
    Title: LINC00665 promotes the progression of acute myeloid leukemia by regulating the miR-4458/DOCK1 pathway.
  5. Circular RNA DOCK1 downregulates microRNA-124 to induce the growth of human thyroid cancer cell lines.
    Title: Circular RNA DOCK1 downregulates microRNA-124 to induce the growth of human thyroid cancer cell lines.
  6. TBOPP enhances the anticancer effect of cisplatin by inhibiting DOCK1 in renal cell carcinoma.
    Title: TBOPP enhances the anticancer effect of cisplatin by inhibiting DOCK1 in renal cell carcinoma.
  7. Identifying and treating ROBO1(-ve) /DOCK1(+ve) prostate cancer: An aggressive cancer subtype prevalent in African American patients.
    Title: Identifying and treating ROBO1(-ve) /DOCK1(+ve) prostate cancer: An aggressive cancer subtype prevalent in African American patients.
  8. CircDOCK1 affected the progression of BC via modulation of circDOCK1/hsa-miR-132-3p/Sox5 pathway.
    Title: Circular RNA DOCK1 promotes bladder carcinoma progression via modulating circDOCK1/hsa-miR-132-3p/Sox5 signalling pathway.
  9. DOCK180 has an indispensable role in pregnancy establishment as knocking down Dock180 abrogates pregnancy by a consolidated impact on decidualization and angiogenesis by regulating AIRE nuclear entry.
    Title: Silencing of dedicator of cytokinesis (DOCK180) obliterates pregnancy by interfering with decidualization due to blockage of nuclear entry of autoimmune regulator (AIRE).
  10. High DOCK1 expression is associated with Oral squamous cell carcinoma.
    Title: CircDOCK1 suppresses cell apoptosis via inhibition of miR‑196a‑5p by targeting BIRC3 in OSCC.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
EBI GWAS Catalog
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
EBI GWAS Catalog
Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity TAS
Traceable Author Statement
more info
 PubMed 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in myoblast fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis, engulfment TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of guanyl-nucleotide exchange factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dedicator of cytokinesis protein 1
Names
180 kDa protein downstream of CRK
DOwnstream of CrK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033919.3 RefSeqGene

    Range
    5002..552090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290223.2 → NP_001277152.2  dedicator of cytokinesis protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
    Consensus CDS
    CCDS76359.1
    UniProtKB/TrEMBL
    A0A096LNH6, A0A2X0U2H5
    Related
    ENSP00000485033.1, ENST00000623213.2

  2. NM_001377543.1 → NP_001364472.1  dedicator of cytokinesis protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
    UniProtKB/TrEMBL
    A0A2X0U2H5
    Conserved Domains (4) summary
    cd08694
    Location:424 → 619
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd12051
    Location:13 → 68
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    pfam16172
    Location:72 → 416
    DOCK_N; DOCK N-terminus
    cl06123
    Location:1214 → 1666
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  3. NM_001377544.1 → NP_001364473.1  dedicator of cytokinesis protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
    UniProtKB/TrEMBL
    A0A2X0U2H5
    Conserved Domains (4) summary
    cd08694
    Location:436 → 631
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd11707
    Location:1226 → 1624
    DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
    pfam16172
    Location:84 → 428
    DOCK_N; DOCK N-terminus
    cl17036
    Location:13 → 80
    SH3; Src Homology 3 domain superfamily

  4. NM_001377546.1 → NP_001364475.1  dedicator of cytokinesis protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
    UniProtKB/TrEMBL
    A0A2X0U2H5
    Conserved Domains (4) summary
    cd08694
    Location:445 → 640
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd12051
    Location:13 → 68
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    pfam16172
    Location:72 → 437
    DOCK_N; DOCK N-terminus
    cl06123
    Location:1235 → 1593
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  5. NM_001377547.1 → NP_001364476.1  dedicator of cytokinesis protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
    UniProtKB/TrEMBL
    A0A2X0U2H5
    Conserved Domains (4) summary
    cd08694
    Location:403 → 598
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd11707
    Location:1193 → 1591
    DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
    cd12051
    Location:13 → 68
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    pfam16172
    Location:72 → 417
    DOCK_N; DOCK N-terminus

  6. NM_001377548.1 → NP_001364477.1  dedicator of cytokinesis protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL157711, AL355316, AL359094, AL390920, AL607029, BX470201
    UniProtKB/TrEMBL
    A0A2X0U2H5
    Conserved Domains (4) summary
    cd08694
    Location:396 → 591
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd11707
    Location:1186 → 1584
    DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
    pfam16172
    Location:44 → 388
    DOCK_N; DOCK N-terminus
    cl17036
    Location:16 → 40
    SH3; Src Homology 3 domain superfamily

  7. NM_001377550.1 → NP_001364479.1  dedicator of cytokinesis protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
    UniProtKB/TrEMBL
    A0A2X0U2H5
    Conserved Domains (4) summary
    cd11707
    Location:1181 → 1579
    DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
    cd12051
    Location:13 → 68
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    pfam16172
    Location:72 → 416
    DOCK_N; DOCK N-terminus
    cl14603
    Location:424 → 586
    C2; C2 domain

  8. NM_001377553.1 → NP_001364482.1  dedicator of cytokinesis protein 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
    UniProtKB/TrEMBL
    A0A2X0U2H5
    Conserved Domains (4) summary
    cd08694
    Location:424 → 619
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd12051
    Location:13 → 68
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    pfam16172
    Location:72 → 416
    DOCK_N; DOCK N-terminus
    cl06123
    Location:1214 → 1572
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  9. NM_001377554.1 → NP_001364483.1  dedicator of cytokinesis protein 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
    UniProtKB/TrEMBL
    A0A2X0U2H5
    Conserved Domains (4) summary
    cd08694
    Location:373 → 568
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd11707
    Location:1163 → 1561
    DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
    cd12051
    Location:13 → 68
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    pfam16172
    Location:72 → 365
    DOCK_N; DOCK N-terminus

  10. NM_001377556.1 → NP_001364485.1  dedicator of cytokinesis protein 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
    UniProtKB/TrEMBL
    A0A2X0U2H5
    Conserved Domains (4) summary
    cd08694
    Location:424 → 619
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd12051
    Location:13 → 68
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    pfam16172
    Location:72 → 416
    DOCK_N; DOCK N-terminus
    cl06123
    Location:1214 → 1547
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  11. NM_001377558.1 → NP_001364487.1  dedicator of cytokinesis protein 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
    UniProtKB/TrEMBL
    A0A2X0U2H5
    Conserved Domains (4) summary
    cd08694
    Location:373 → 568
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd11707
    Location:1145 → 1543
    DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
    cd12051
    Location:13 → 68
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    pfam16172
    Location:72 → 365
    DOCK_N; DOCK N-terminus

  12. NM_001377560.1 → NP_001364489.1  dedicator of cytokinesis protein 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL157711, AL355316, AL359094, AL390920, AL607029, BX470155
    UniProtKB/TrEMBL
    A0A2X0U2H5
    Conserved Domains (4) summary
    cd08694
    Location:160 → 355
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd11707
    Location:950 → 1348
    DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
    pfam16172
    Location:44 → 152
    DOCK_N; DOCK N-terminus
    cl17036
    Location:13 → 43
    SH3; Src Homology 3 domain superfamily

  13. NM_001377561.1 → NP_001364490.1  dedicator of cytokinesis protein 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL359094, AL390920, AL607029, BX470155, BX470201
    Conserved Domains (3) summary
    cd08694
    Location:445 → 640
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd12051
    Location:13 → 68
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    pfam16172
    Location:72 → 437
    DOCK_N; DOCK N-terminus

  14. NM_001380.5 → NP_001371.2  dedicator of cytokinesis protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
    Consensus CDS
    CCDS73222.1
    UniProtKB/Swiss-Prot
    A9Z1Z5, Q14185
    UniProtKB/TrEMBL
    A0A2X0U2H5
    Related
    ENSP00000280333.6, ENST00000280333.9
    Conserved Domains (4) summary
    cd08694
    Location:424 → 619
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd11707
    Location:1214 → 1612
    DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
    cd12051
    Location:13 → 68
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    pfam16172
    Location:72 → 416
    DOCK_N; DOCK N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    126905428..127452516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424701.1 → XP_047280657.1  dedicator of cytokinesis protein 1 isoform X6

  2. XM_047424703.1 → XP_047280659.1  dedicator of cytokinesis protein 1 isoform X9

  3. XM_017015813.3 → XP_016871302.1  dedicator of cytokinesis protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A2X0U2H5

  4. XM_011539422.4 → XP_011537724.1  dedicator of cytokinesis protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A2X0U2H5
    Conserved Domains (4) summary
    cd08694
    Location:467 → 662
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd11707
    Location:1257 → 1655
    DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
    cd12051
    Location:37 → 90
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    pfam16172
    Location:94 → 459
    DOCK_N; DOCK N-terminus

  5. XM_017015814.2 → XP_016871303.1  dedicator of cytokinesis protein 1 isoform X4

  6. XM_047424700.1 → XP_047280656.1  dedicator of cytokinesis protein 1 isoform X5

  7. XM_017015817.1 → XP_016871306.1  dedicator of cytokinesis protein 1 isoform X7

  8. XM_047424702.1 → XP_047280658.1  dedicator of cytokinesis protein 1 isoform X8

  9. XM_011539424.2 → XP_011537726.1  dedicator of cytokinesis protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A2X0U2H5
    Conserved Domains (4) summary
    cd08694
    Location:439 → 634
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd11707
    Location:1229 → 1627
    DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
    pfam16172
    Location:66 → 431
    DOCK_N; DOCK N-terminus
    cl17036
    Location:9 → 62
    SH3; Src Homology 3 domain superfamily

RNA

  1. XR_007061946.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    127789114..128347493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364961.1 → XP_054220936.1  dedicator of cytokinesis protein 1 isoform X6

  2. XM_054364964.1 → XP_054220939.1  dedicator of cytokinesis protein 1 isoform X9

  3. XM_054364957.1 → XP_054220932.1  dedicator of cytokinesis protein 1 isoform X2

  4. XM_054364956.1 → XP_054220931.1  dedicator of cytokinesis protein 1 isoform X1

  5. XM_054364959.1 → XP_054220934.1  dedicator of cytokinesis protein 1 isoform X4

  6. XM_054364960.1 → XP_054220935.1  dedicator of cytokinesis protein 1 isoform X5

  7. XM_054364962.1 → XP_054220937.1  dedicator of cytokinesis protein 1 isoform X7

  8. XM_054364963.1 → XP_054220938.1  dedicator of cytokinesis protein 1 isoform X8

  9. XM_054364958.1 → XP_054220933.1  dedicator of cytokinesis protein 1 isoform X3

RNA

  1. XR_008488170.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14185.2 GenPept UniProtKB/Swiss-Prot:Q14185

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