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C37C3.2 Eukaryotic translation initiation factor 5 [ Caenorhabditis elegans ]

Gene ID: 179165, updated on 5-May-2024

Summary

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Gene symbol
C37C3.2
Gene description
Eukaryotic translation initiation factor 5
Primary source
WormBase:WBGene00016496
Locus tag
CELE_C37C3.2
See related
AllianceGenome:WB:WBGene00016496
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GDP-dissociation inhibitor activity; eukaryotic initiation factor eIF2 binding activity; and translation initiation factor activity. Involved in translation. Predicted to be active in cytosol. Is expressed in body wall musculature; excretory cell; intestine; nervous system; and pharynx. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (7855944..7857948)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Eukaryotic translation initiation factor 5 Neighboring gene DUF1768 domain-containing protein;NADAR domain-containing protein Neighboring gene WAP domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling. Lee EC, et al. Am J Physiol Cell Physiol, 2012 Dec 15. PMID 23076791, Free PMC Article
  2. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article
  3. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Crawford ED, et al. Cell Death Differ, 2012 Dec. PMID 22918439, Free PMC Article
  4. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic initiation factor eIF2 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in formation of cytoplasmic translation initiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Eukaryotic translation initiation factor 5
NP_001370553.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    7855944..7857948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383347.2 → NP_001370553.1  Eukaryotic translation initiation factor 5 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22918, Q95Q70
    Conserved Domains (2) summary
    cd11561
    Location:216 → 370
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:9 → 126
    eIF-5_eIF-2B; Domain found in IF2B/IF5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22918.2

Gene LinkOut

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