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Myl6 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle [ Mus musculus (house mouse) ]

Gene ID: 17904, updated on 3-Apr-2024

Summary

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Official Symbol
Myl6provided by MGI
Official Full Name
myosin, light polypeptide 6, alkali, smooth muscle and non-muscleprovided by MGI
Primary source
MGI:MGI:109318
See related
Ensembl:ENSMUSG00000090841 AllianceGenome:MGI:109318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LC17; Myln; ESMLC; MLC-3; MLC1SM; LC17-GI
Summary
Predicted to be a structural constituent of muscle. Predicted to be involved in muscle filament sliding and skeletal muscle tissue development. Part of unconventional myosin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human MYL6 (myosin light chain 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 2188.3), placenta adult (RPKM 580.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D3; 10 76.75 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128326728..128329755, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128490859..128493886, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene microRNA 8105 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E1816 Neighboring gene myosin, light polypeptide 6B Neighboring gene STARR-positive B cell enhancer ABC_E8378 Neighboring gene Riken cDNA A430046D13 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of nonmuscle myosin light chain 3 gene expression in response to exogenous MLC3nm mRNA. Hailstones D, et al. Cell Mol Biol Res, 1994. PMID 7804326
  2. Changing patterns of gene expression in developing mouse kidney, as probed by differential mRNA display combined with cDNA library screening. Rosenblum ND, et al. Kidney Int, 1997 Mar. PMID 9067931
  3. Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction. Yuan S, et al. Proc Natl Acad Sci U S A, 2015 Feb 3. PMID 25605924, Free PMC Article
  4. Expression of the dystrophin-related protein 2 (Drp2) transcript in the mouse. Dixon AK, et al. J Mol Biol, 1997 Jul 25. PMID 9245586
  5. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. Hailstones DL, et al. Mol Cell Biol, 1990 Mar. PMID 2304459, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC106465, MGC107135

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of muscle IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of muscle ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of muscle TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in muscle filament sliding TAS
Traceable Author Statement
more info
 PubMed 
involved_in skeletal muscle tissue development TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex TAS
Traceable Author Statement
more info
 PubMed 
part_of unconventional myosin complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myosin light polypeptide 6
Names
17 kDa myosin light chain
myosin light chain A3
myosin light chain alkali 3
myosin light chain, alkali, nonmuscle
smooth muscle and nonmuscle myosin light chain alkali 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317217.2 → NP_001304146.1  myosin light polypeptide 6 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 6 both encode the same isoform (a).
    Source sequence(s)
    AC170752
    Consensus CDS
    CCDS88111.1
    UniProtKB/TrEMBL
    A0A1W2P6F6, A0A1W2P7Q9
    Related
    ENSMUSP00000151915.2, ENSMUST00000219236.2
    Conserved Domains (3) summary
    smart00054
    Location:11 → 39
    EFh; EF-hand, calcium binding motif
    cd00051
    Location:94 → 144
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl08302
    Location:11 → 75
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_001317218.2 → NP_001304147.1  myosin light polypeptide 6 isoform MLC3nm

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, resulting in a framehsift and a novel 3' UTR, compared to variant 1. The encoded isoform (MLC3nm, also known as LC17A and LC17-nm) has a distinct C-terminus and is shorter than isoform a. Isoforms MLC3nm and MLC3sm are the same length but differ in their C-termini.
    Source sequence(s)
    AC170752
    Consensus CDS
    CCDS88112.1
    UniProtKB/Swiss-Prot
    Q60605
    UniProtKB/TrEMBL
    A0A1W2P6F6
    Related
    ENSMUSP00000151693.2, ENSMUST00000218127.2
    Conserved Domains (1) summary
    PTZ00184
    Location:5 → 150
    PTZ00184; calmodulin; Provisional

  3. NM_001317219.2 → NP_001304148.1  myosin light polypeptide 6 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in distinct 5' and 3' UTRs, translation initiation at a downstream start codon, and a frameshift, compared to variant 1. The encoded isoform (b) has a shorter N-terminus and a distinct C-terminus, compared to isoform a. Isoforms b and c are the same length but differ in their C-termini. Variants 4 and 11 both encode the same isoform (b).
    Source sequence(s)
    AC170752
    Conserved Domains (1) summary
    PTZ00184
    Location:1 → 115
    PTZ00184; calmodulin; Provisional

  4. NM_001317220.2 → NP_001304149.1  myosin light polypeptide 6 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 1. These differences result in distinct 5' and 3' UTRs, translation initiation at a downstream start codon, and a frameshift, compared to variant 1. The encoded isoform (c) has a shorter N-terminus and a distinct C-terminus, compared to isoform a. Isoforms b and c are the same length but differ in their C-termini. Variants 5, 9, and 10 all encode the same isoform (c).
    Source sequence(s)
    AC170752
    Conserved Domains (1) summary
    PTZ00184
    Location:1 → 114
    PTZ00184; calmodulin; Provisional

  5. NM_001428663.1 → NP_001415592.1  myosin light polypeptide 6 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC170752
    UniProtKB/TrEMBL
    A0A1W2P7Q9

  6. NM_001428664.1 → NP_001415593.1  myosin light polypeptide 6 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC170752

  7. NM_001428665.1 → NP_001415594.1  myosin light polypeptide 6 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC170752
    UniProtKB/TrEMBL
    A0A1W2P6G5

  8. NM_001428667.1 → NP_001415596.1  myosin light polypeptide 6 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC170752

  9. NM_001428668.1 → NP_001415597.1  myosin light polypeptide 6 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC170752

  10. NM_001428672.1 → NP_001415601.1  myosin light polypeptide 6 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC170752

  11. NM_001428673.1 → NP_001415602.1  myosin light polypeptide 6 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC170752

  12. NM_001428675.1 → NP_001415604.1  myosin light polypeptide 6 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC170752

  13. NM_001428677.1 → NP_001415606.1  myosin light polypeptide 6 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variant 15, encodes isoform h.
    Source sequence(s)
    AC170752

  14. NM_001428678.1 → NP_001415607.1  myosin light polypeptide 6 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC170752

  15. NM_001428679.1 → NP_001415608.1  myosin light polypeptide 6 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC170752

  16. NM_001428680.1 → NP_001415609.1  myosin light polypeptide 6 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC170752

  17. NM_001428681.1 → NP_001415610.1  myosin light polypeptide 6 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC170752

  18. NM_010860.5 → NP_034990.1  myosin light polypeptide 6 isoform MLC3sm

    See identical proteins and their annotated locations for NP_034990.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, resulting in a frameshift and a novel 3' UTR, compared to variant 1. The encoded isoform (MLC3sm, also known as LC17B and LC17-sm) has a distinct C-terminus and is shorter than isoform a. Isoforms MLC3sm and MLC3nm are the same length but differ in their C-termini. Isoforms b and c are the same length but differ in their C-termini.
    Source sequence(s)
    AC170752
    Consensus CDS
    CCDS48728.1
    UniProtKB/TrEMBL
    A0A1W2P6F6, Q642K0
    Related
    ENSMUSP00000128803.2, ENSMUST00000164181.2
    Conserved Domains (1) summary
    PTZ00184
    Location:5 → 149
    PTZ00184; calmodulin; Provisional

RNA

  1. NR_190456.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC170752

  2. NR_190457.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC170752

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128326728..128329755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155669.1 → XP_036011562.1  myosin light polypeptide 6 isoform X1

    Conserved Domains (1) summary
    PTZ00184
    Location:1 → 114
    PTZ00184; calmodulin; Provisional

  2. XM_036155670.1 → XP_036011563.1  myosin light polypeptide 6 isoform X2

    Conserved Domains (1) summary
    PTZ00184
    Location:1 → 115
    PTZ00184; calmodulin; Provisional

  3. XM_030244939.2 → XP_030100799.1  myosin light polypeptide 6 isoform X2

    Conserved Domains (1) summary
    PTZ00184
    Location:1 → 115
    PTZ00184; calmodulin; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60605.3 GenPept UniProtKB/Swiss-Prot:Q60605

Gene LinkOut

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