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mcm-7 DNA replication licensing factor MCM7 [ Caenorhabditis elegans ]

Gene ID: 178831, updated on 25-Apr-2024

Summary

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Gene symbol
mcm-7
Gene description
DNA replication licensing factor MCM7
Primary source
WormBase:WBGene00003159
Locus tag
CELE_F32D1.10
See related
AllianceGenome:WB:WBGene00003159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Involved in MCM complex assembly; embryo development; and mitotic sister chromatid segregation. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in body wall musculature; head; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MCM7 (minichromosome maintenance complex component 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (4347166..4349768)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene AAA domain-containing protein;Fidgetin-like protein 1;Spastin/Vps4 C-terminal domain-containing protein Neighboring gene ATP synthase subunit epsilon, mitochondrial Neighboring gene TPR_REGION domain-containing protein;dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene ncRNA Neighboring gene Ground-like domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. Woodward AM, et al. J Cell Biol, 2006 Jun 5. PMID 16754955, Free PMC Article
  2. Minichromosome maintenance protein 5 homologue in Caenorhabditis elegans plays essential role for postembryonic development. Wang X, et al. Biochem Biophys Res Commun, 2007 Aug 10. PMID 17568563
  3. Http://C. elegans: mining the functional genomic landscape. Kim SK. Nat Rev Genet, 2001 Sep. PMID 11533717
  4. The dynamics of replication licensing in live Caenorhabditis elegans embryos. Sonneville R, et al. J Cell Biol, 2012 Jan 23. PMID 22249291, Free PMC Article
  5. LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis. Hong Y, et al. Nat Commun, 2018 Feb 20. PMID 29463814, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in MCM complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic sister chromatid segregation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
  
part_of MCM complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA replication licensing factor MCM7
NP_504199.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    4347166..4349768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071798.9 → NP_504199.1  DNA replication licensing factor MCM7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504199.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16297
    Conserved Domains (4) summary
    smart00350
    Location:162 → 651
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:16 → 178
    MCM_N; MCM N-terminal domain
    cl00588
    Location:619 → 715
    CarD_CdnL_TRCF; CarD-like/TRCF domain
    cl21455
    Location:385 → 524
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
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