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Myef2 myelin basic protein expression factor 2, repressor [ Mus musculus (house mouse) ]

Gene ID: 17876, updated on 3-Apr-2024

Summary

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Official Symbol
Myef2provided by MGI
Official Full Name
myelin basic protein expression factor 2, repressorprovided by MGI
Primary source
MGI:MGI:104592
See related
Ensembl:ENSMUSG00000027201 AllianceGenome:MGI:104592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1341; 9430071B01
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of post-mRNA release spliceosomal complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; liver; sensory organ; thymus; and vertebral axis musculature. Orthologous to human MYEF2 (myelin expression factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 22.6), CNS E14 (RPKM 21.9) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F1; 2 61.16 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (124922894..124966727, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125080975..125123660, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5974 Neighboring gene predicted gene, 39920 Neighboring gene predicted gene, 52495 Neighboring gene STARR-seq mESC enhancer starr_05578 Neighboring gene STARR-seq mESC enhancer starr_05579 Neighboring gene STARR-seq mESC enhancer starr_05581 Neighboring gene solute carrier family 24, member 5 Neighboring gene STARR-seq mESC enhancer starr_05583 Neighboring gene predicted gene, 22352 Neighboring gene predicted gene, 46759 Neighboring gene cortexin 2 Neighboring gene solute carrier family 12, member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:125014961-125015261 Neighboring gene predicted gene, 46760

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evidence for inhibition of MyEF-2 binding to MBP promoter by MEF-1/Pur alpha. Muralidharan V, et al. J Cell Biochem, 1997 Sep 15. PMID 9282330
  2. Regulation of mouse myelin basic protein gene transcription by a sequence-specific single-stranded DNA-binding protein in vitro. Steplewski A, et al. Gene, 1995 Mar 10. PMID 7534248
  3. Identification of a sequence-specific single-stranded DNA binding protein that suppresses transcription of the mouse myelin basic protein gene. Haas S, et al. J Biol Chem, 1995 May 26. PMID 7539003
  4. A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells. van Riel B, et al. Mol Cell Biol, 2012 Oct. PMID 22801375, Free PMC Article
  5. High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Ehringer MA, et al. Mamm Genome, 2001 Aug. PMID 11471062

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RUNX1 interacts with two novel protein partners, LSD1 and MYEF2, in erythroid cells.
    Title: A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myelin expression factor 2
Names
MEF-2
myEF-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162417.2 → NP_001155889.1  myelin expression factor 2 isoform 1

    See identical proteins and their annotated locations for NP_001155889.1

    Status: VALIDATED

    Source sequence(s)
    AL928902, AL929451
    Consensus CDS
    CCDS50691.1
    UniProtKB/Swiss-Prot
    Q60690, Q6P930, Q6ZPT3, Q8C854, Q8QZZ1
    UniProtKB/TrEMBL
    A2ATP6
    Related
    ENSMUSP00000123088.2, ENSMUST00000152367.8
    Conserved Domains (4) summary
    TIGR01628
    Location:115 → 587
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12658
    Location:92 → 167
    RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12660
    Location:224 → 299
    RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:515 → 591
    RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

  2. NM_001162418.2 → NP_001155890.1  myelin expression factor 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL928902, AL929451
    Consensus CDS
    CCDS50689.1
    UniProtKB/TrEMBL
    A2ATP5, A2ATP6
    Related
    ENSMUSP00000114817.2, ENSMUST00000147105.8
    Conserved Domains (4) summary
    TIGR01628
    Location:115 → 546
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:226 → 299
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:92 → 167
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:474 → 550
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

  3. NM_001401843.1 → NP_001388772.1  myelin expression factor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL928902, AL929451
    UniProtKB/Swiss-Prot
    Q60690, Q6P930, Q6ZPT3, Q8C854, Q8QZZ1

  4. NM_010852.3 → NP_034982.2  myelin expression factor 2 isoform 2

    See identical proteins and their annotated locations for NP_034982.2

    Status: VALIDATED

    Source sequence(s)
    AL928902, AL929451
    Consensus CDS
    CCDS50690.1
    UniProtKB/TrEMBL
    A7UQY4
    Related
    ENSMUSP00000066312.4, ENSMUST00000067780.10
    Conserved Domains (4) summary
    TIGR01628
    Location:115 → 570
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:226 → 299
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:92 → 167
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:498 → 574
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    124922894..124966727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248228.2 → XP_030104088.1  myelin expression factor 2 isoform X3

    UniProtKB/TrEMBL
    A2ATP5, A2ATP6
    Conserved Domains (4) summary
    TIGR01628
    Location:115 → 546
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:226 → 299
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:92 → 167
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:474 → 550
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

  2. XM_006498884.4 → XP_006498947.1  myelin expression factor 2 isoform X2

    See identical proteins and their annotated locations for XP_006498947.1

    UniProtKB/TrEMBL
    A7UQY4
    Conserved Domains (4) summary
    TIGR01628
    Location:115 → 570
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:226 → 299
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:92 → 167
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:498 → 574
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

  3. XM_017316131.3 → XP_017171620.1  myelin expression factor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q60690, Q6P930, Q6ZPT3, Q8C854, Q8QZZ1
    UniProtKB/TrEMBL
    A2ATP6
    Conserved Domains (4) summary
    TIGR01628
    Location:115 → 587
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12658
    Location:92 → 167
    RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12660
    Location:224 → 299
    RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:515 → 591
    RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

  4. XM_017316134.3 → XP_017171623.1  myelin expression factor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q60690, Q6P930, Q6ZPT3, Q8C854, Q8QZZ1
    UniProtKB/TrEMBL
    A2ATP6
    Conserved Domains (4) summary
    TIGR01628
    Location:115 → 587
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12658
    Location:92 → 167
    RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12660
    Location:224 → 299
    RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:515 → 591
    RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

  5. XM_017316132.3 → XP_017171621.1  myelin expression factor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q60690, Q6P930, Q6ZPT3, Q8C854, Q8QZZ1
    UniProtKB/TrEMBL
    A2ATP6
    Conserved Domains (4) summary
    TIGR01628
    Location:115 → 587
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12658
    Location:92 → 167
    RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12660
    Location:224 → 299
    RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:515 → 591
    RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

RNA

  1. XR_001781149.3 RNA Sequence

  2. XR_001781148.3 RNA Sequence

  3. XR_004938788.1 RNA Sequence

  4. XR_004938787.1 RNA Sequence

  5. XR_001781147.3 RNA Sequence

  6. XR_001781150.1 RNA Sequence

  7. XR_001781152.3 RNA Sequence

  8. XR_004938789.1 RNA Sequence

  9. XR_001781151.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C854.1 GenPept UniProtKB/Swiss-Prot:Q8C854

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