Gadd45b growth arrest and DNA-damage-inducible 45 beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gadd45bprovided by MGI
Official Full Name: growth arrest and DNA-damage-inducible 45 betaprovided by MGI
Primary source: MGI:MGI:107776
See related: Ensembl:ENSMUSG00000015312 AllianceGenome:MGI:107776
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Myd118
Summary: Acts upstream of or within negative regulation of protein kinase activity; positive regulation of MAPK cascade; and regulation of cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including arterial system; forelimb bud; future brain; sensory organ; and somite. Orthologous to human GADD45B (growth arrest and DNA damage inducible beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 41.2), ovary adult (RPKM 20.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80765925..80768038)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (80930091..80932204)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gadd45beta is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation.
Title: Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation.
GADD45A and GADD45B as Novel Biomarkers Associated with Chromatin Regulators in Renal Ischemia-Reperfusion Injury.
Title: GADD45A and GADD45B as Novel Biomarkers Associated with Chromatin Regulators in Renal Ischemia-Reperfusion Injury.
Hepatic Gadd45beta promotes hyperglycemia and glucose intolerance through DNA demethylation of PGC-1alpha.
Title: Hepatic Gadd45β promotes hyperglycemia and glucose intolerance through DNA demethylation of PGC-1α.
Ablation of Gadd45beta ameliorates the inflammation and renal fibrosis caused by unilateral ureteral obstruction.
Title: Ablation of Gadd45β ameliorates the inflammation and renal fibrosis caused by unilateral ureteral obstruction.
Gadd45b mediates depressive-like role through DNA demethylation.
Title: Gadd45b mediates depressive-like role through DNA demethylation.
Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g.
Title: Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g.
these results indicate that the Gadd45b-regulated TGF-b signaling pathway is involved in wound healing by enhancing epithelial restitution. These results expand the current understanding of the function of Gadd45b and its therapeutic potential in ulcerative colitis.
Title: Gadd45β promotes regeneration after injury through TGFβ-dependent restitution in experimental colitis.
Gadd45a,b double-mutant mouse embryos display embryonic sublethality, deregulated ZGA gene expression, and developmental arrestrevealing an unexpected role of GADD45 proteins in embryonic two-cell stage regulation
Title: GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells.
High GADD45B expression is associated with cancer.
Title: GADD45β Loss Ablates Innate Immunosuppression in Cancer.
Results indicate a role for Gadd45b in stress-induced senescence and in tissue aging.
Title: Gadd45b deficiency promotes premature senescence and skin aging.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

X54149 (e-PCR)
- UniSTS:160008

Gadd45b (e-PCR), detects polymorphism
- UniSTS:143942

Gadd45b (e-PCR), detects polymorphism
- UniSTS:496735

AI323528 (e-PCR)
- UniSTS:180066

NoName (e-PCR)
- UniSTS:546779

Gadd45b (e-PCR), detects polymorphism
- UniSTS:546779

Gadd45b (e-PCR), detects polymorphism
- UniSTS:546780

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: growth arrest and DNA damage-inducible protein GADD45 beta

Names: myeloid differentiation primary response gene 118; myeloid differentiation primary response protein MyD118; negative growth regulatory protein MyD118

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008655.1 → NP_032681.1 growth arrest and DNA damage-inducible protein GADD45 beta

See identical proteins and their annotated locations for NP_032681.1

Status: PROVISIONAL

Source sequence(s)

X54149

Consensus CDS

CCDS24038.1

UniProtKB/Swiss-Prot

P22339, Q3U342, Q9R106

UniProtKB/TrEMBL

A0A1W2P6W4

Related

ENSMUSP00000015456.9, ENSMUST00000015456.10

Conserved Domains (1) summary

pfam01248
Location:21 → 120

Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family