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gtf-2E1 HTH TFE/IIEalpha-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178502, updated on 23-Nov-2023

Summary

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Gene symbol
gtf-2E1
Gene description
HTH TFE/IIEalpha-type domain-containing protein
Primary source
WormBase:WBGene00013998
Locus tag
CELE_ZK550.4
See related
AllianceGenome:WB:WBGene00013998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase II complex binding activity. Involved in transcription initiation from RNA polymerase II promoter. Part of transcription factor TFIIE complex. Orthologous to human GTF2E1 (general transcription factor IIE subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (17255301..17257562)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene Peptidase M3A/M3B catalytic domain-containing protein Neighboring gene ncRNA Neighboring gene phytanoyl-CoA dioxygenase Neighboring gene ncRNA Neighboring gene putative phytanoyl-CoA dioxygenase Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation. Yamamoto S, et al. Mol Cell Biol, 2001 Jan. PMID 11113176, Free PMC Article
  2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA polymerase II complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription open complex formation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of transcription factor TFIIE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIE complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
HTH TFE/IIEalpha-type domain-containing protein
NP_503060.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    17255301..17257562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070659.9 → NP_503060.1  HTH TFE/IIEalpha-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503060.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG49
    Conserved Domains (2) summary
    smart00531
    Location:41 → 188
    TFIIE; Transcription initiation factor IIE
    pfam11521
    Location:354 → 426
    TFIIE-A_C; C-terminal general transcription factor TFIIE alpha
Nucleotide Protein
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