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cpt-2 Calponin-homology (CH) domain-containing protein;Choline/carnitine acyltransferase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178025, updated on 11-Apr-2024

Summary

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Gene symbol
cpt-2
Gene description
Calponin-homology (CH) domain-containing protein;Choline/carnitine acyltransferase domain-containing protein
Primary source
WormBase:WBGene00011122
Locus tag
CELE_R07H5.2
See related
AllianceGenome:WB:WBGene00011122
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable carnitine O-palmitoyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Is expressed in intestine. Human ortholog(s) of this gene implicated in brain disease; lipid metabolism disorder; and muscular disease. Orthologous to human CPT2 (carnitine palmitoyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
10
Sequence:
Chromosome: IV; NC_003282.8 (11179645..11183008)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RAP homolog (vertebrate Rap GTPase family) Neighboring gene Uncharacterized protein Neighboring gene Peroxisomal membrane protein PEX14 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 Neighboring gene SKN-1 Dependent Zygotic transcript

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prowashonupana barley dietary fibre reduces body fat and increases insulin sensitivity in Caenorhabditis elegans model. Gao C, et al. J Funct Foods, 2015 Oct. PMID 27721901, Free PMC Article
  2. Oat consumption reduced intestinal fat deposition and improved health span in Caenorhabditis elegans model. Gao C, et al. Nutr Res, 2015 Sep. PMID 26253816, Free PMC Article
  3. Evolutionary analysis of the carnitine- and choline acyltransferases suggests distinct evolution of CPT2 versus CPT1 and related variants. van der Hoek MD, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Aug. PMID 29730527
  4. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article
  5. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine O-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Calponin-homology (CH) domain-containing protein;Choline/carnitine acyltransferase domain-containing protein
NP_001040977.2
  • Confirmed by transcript evidence
NP_001040978.2
  • Confirmed by transcript evidence
NP_001294004.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11179645..11183008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047512.5 → NP_001040977.2  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040977.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECS9
    Conserved Domains (1) summary
    pfam00755
    Location:42 → 639
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

  2. NM_001047513.5 → NP_001040978.2  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040978.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFE6
    Conserved Domains (1) summary
    pfam00755
    Location:16 → 469
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

  3. NM_001307075.3 → NP_001294004.1  Choline/carnitine acyltransferase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294004.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AL65
    Conserved Domains (1) summary
    pfam00755
    Location:1 → 102
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
Nucleotide Protein
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