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rpn-7 26S proteasome non-ATPase regulatory subunit 6 [ Caenorhabditis elegans ]

Gene ID: 177753, updated on 5-May-2024

Summary

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Gene symbol
rpn-7
Gene description
26S proteasome non-ATPase regulatory subunit 6
Primary source
WormBase:WBGene00004463
Locus tag
CELE_F49C12.8
See related
AllianceGenome:WB:WBGene00004463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable enzyme regulator activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle. Is expressed in several structures, including anal depressor muscle; excretory cell; intestine; pharynx; and reproductive system. Orthologous to human PSMD6 (proteasome 26S subunit, non-ATPase 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (9316639..9318632)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein 144 Neighboring gene CHK kinase-like domain-containing protein Neighboring gene UBA domain-containing protein Neighboring gene Methyltransferase type 11 domain-containing protein Neighboring gene Translation machinery-associated protein 7 homolog Neighboring gene DUF1648 domain-containing protein;Ribonuclease kappa Neighboring gene V-type proton ATPase subunit e Neighboring gene DUF19 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of MBK-2/Dyrk kinase by dynamic cortical anchoring during the oocyte-to-zygote transition. Stitzel ML, et al. Curr Biol, 2007 Sep 18. PMID 17869113
  2. A functional genomic screen for evolutionarily conserved genes required for lifespan and immunity in germline-deficient C. elegans. Sinha A, et al. PLoS One, 2014. PMID 25093668, Free PMC Article
  3. The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Choe KP, et al. Mol Cell Biol, 2009 May. PMID 19273594, Free PMC Article
  4. Coordinate activation of maternal protein degradation during the egg-to-embryo transition in C. elegans. Pellettieri J, et al. Dev Cell, 2003 Sep. PMID 12967564
  5. Regulation of the C. elegans molt by pqn-47. Russel S, et al. Dev Biol, 2011 Dec 15. PMID 21989027, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 6
NP_501632.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9316639..9318632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069231.7 → NP_501632.1  26S proteasome non-ATPase regulatory subunit 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501632.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20585
    Conserved Domains (3) summary
    COG5187
    Location:21 → 403
    RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]
    pfam01399
    Location:274 → 379
    PCI; PCI domain
    pfam10602
    Location:80 → 253
    RPN7; 26S proteasome subunit RPN7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20585.1

Gene LinkOut

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