pole-2 putative DNA polymerase epsilon subunit 2 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: pole-2
Gene description: putative DNA polymerase epsilon subunit 2
Primary source: WormBase:WBGene00017237
Locus tag: CELE_F08B4.5
See related: AllianceGenome:WB:WBGene00017237
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity. Predicted to be involved in DNA-dependent DNA replication and error-prone translesion synthesis. Predicted to be located in nucleus. Predicted to be part of epsilon DNA polymerase complex. Orthologous to human POLE2 (DNA polymerase epsilon 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 11

Sequence:: Chromosome: IV; NC_003282.8 (8682240..8686610, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F08B4.7 (e-PCR)
- UniSTS:316550

F08B4.5 (e-PCR)
- UniSTS:314017

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated DNA replication	IEA Inferred from Electronic Annotation more info
involved_in error-prone translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of epsilon DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of epsilon DNA polymerase complex	IEA Inferred from Electronic Annotation more info
located_in nuclear lumen	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative DNA polymerase epsilon subunit 2

NP_501489.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8682240..8686610 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069088.8 → NP_501489.3 putative DNA polymerase epsilon subunit 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501489.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19196

Conserved Domains (2) summary

pfam04042
Location:276 → 475

DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B

pfam12213
Location:6 → 78

Dpoe2NT; DNA polymerases epsilon N terminal