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rsp-6 putative splicing factor, arginine/serine-rich 6 [ Caenorhabditis elegans ]

Gene ID: 177566, updated on 5-May-2024

Summary

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Gene symbol
rsp-6
Gene description
putative splicing factor, arginine/serine-rich 6
Primary source
WormBase:WBGene00004703
Locus tag
CELE_C33H5.12
See related
AllianceGenome:WB:WBGene00004703
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Involved in gonad development and regulation of DNA-templated transcription, termination. Located in nucleus. Is expressed in several structures, including intestine. Orthologous to human SRSF3 (serine and arginine rich splicing factor 3) and SRSF7 (serine and arginine rich splicing factor 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (7789847..7791229, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene IntraMembrane Protease (IMPAS) family Neighboring gene CYSTM domain-containing protein Neighboring gene Nucleoside-triphosphatase ntp-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unique and redundant functions of SR proteins, a conserved family of splicing factors, in Caenorhabditis elegans development. Kawano T, et al. Mech Dev, 2000 Jul. PMID 10906451
  2. Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Longman D, et al. Genes Dev, 2007 May 1. PMID 17437990, Free PMC Article
  3. Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons. Antonacci S, et al. G3 (Bethesda), 2015 Feb 10. PMID 25673135, Free PMC Article
  4. Functional characterization of SR and SR-related genes in Caenorhabditis elegans. Longman D, et al. EMBO J, 2000 Apr 3. PMID 10747030, Free PMC Article
  5. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in gonad development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of termination of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sex differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative splicing factor, arginine/serine-rich 6
NP_741446.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7789847..7791229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171383.6 → NP_741446.1  putative splicing factor, arginine/serine-rich 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741446.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18409, Q8WSW0, Q8WSW1
    Conserved Domains (2) summary
    COG0724
    Location:2 → 75
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12373
    Location:4 → 75
    RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins

RNA

  1. NR_131573.1 RNA Sequence

    Status: REVIEWED

  2. NR_131574.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18409.1

Gene LinkOut

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