U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dif-1 Protein dif-1 [ Caenorhabditis elegans ]

Gene ID: 177530, updated on 23-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
dif-1
Gene description
Protein dif-1
Primary source
WormBase:WBGene00000996
Locus tag
CELE_F49E8.5
See related
AllianceGenome:WB:WBGene00000996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP:ADP antiporter activity. Involved in mitochondrial transport. Located in mitochondrial envelope. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in carnitine-acylcarnitine translocase deficiency. Orthologous to human SLC25A20 (solute carrier family 25 member 20). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (7551657..7552874, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Puromycin-sensitive aminopeptidase Neighboring gene Cytidine deaminase Neighboring gene C2H2-type domain-containing protein Neighboring gene Early nodulin-75-like Neighboring gene BACK domain-containing protein Neighboring gene Phosphatidylinositol-glycan biosynthesis class F protein Neighboring gene Nitrogen permease regulator 2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. dif-1 and colt, both implicated in early embryonic development, encode carnitine acylcarnitine translocase. Oey NA, et al. Mol Genet Metab, 2005 Jun. PMID 15896656
  2. Embryonic tissue differentiation in Caenorhabditis elegans requires dif-1, a gene homologous to mitochondrial solute carriers. Ahringer J. EMBO J, 1995 May 15. PMID 7774589, Free PMC Article
  3. Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Kamath RS, et al. Genome Biol, 2001. PMID 11178279, Free PMC Article
  4. The art and design of genetic screens: caenorhabditis elegans. Jorgensen EM, et al. Nat Rev Genet, 2002 May. PMID 11988761
  5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP:ADP antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables acyl carnitine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in acyl carnitine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in carnitine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial ADP transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial ATP transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial envelope IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Protein dif-1
NP_001379917.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7551657..7552874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392331.1 → NP_001379917.1  Protein dif-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20630, Q27257
    Conserved Domains (1) summary
    pfam00153
    Location:100 → 198
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27257.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous