sfrp-1 NTR domain-containing protein;Secreted frizzled-related protein 1;Secreted frizzled-related protein 5-like [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: sfrp-1
Gene description: NTR domain-containing protein;Secreted frizzled-related protein 1;Secreted frizzled-related protein 5-like
Primary source: WormBase:WBGene00022242
Locus tag: CELE_Y73B6BL.21
See related: AllianceGenome:WB:WBGene00022242
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable Wnt-protein binding activity. Predicted to be involved in canonical Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway; and non-canonical Wnt signaling pathway. Located in nucleus. Is expressed in head muscle and ventral cord neurons. Orthologous to human SFRP1 (secreted frizzled related protein 1); SFRP2 (secreted frizzled related protein 2); and SFRP5 (secreted frizzled related protein 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See sfrp-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (6396574..6402436, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: NTR domain-containing protein;Secreted frizzled-related protein 1;Secreted frizzled-related protein 5-like

NP_001293776.2

Confirmed by transcript evidence

NP_001299990.1

Confirmed by transcript evidence

NP_001368402.1

Confirmed by transcript evidence

NP_500977.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6396574..6402436 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068576.7 → NP_500977.2 Secreted frizzled-related protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500977.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9GUF5

Conserved Domains (2) summary

cd03580
Location:162 → 283

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

cl02447
Location:37 → 161

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
NM_001313061.3 → NP_001299990.1 Secreted frizzled-related protein 5-like [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ARM8

Conserved Domains (2) summary

cl02447
Location:1 → 107

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

cl02512
Location:108 → 229

NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
NM_001306847.2 → NP_001293776.2 NTR domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLQ6
NM_001380275.1 → NP_001368402.1 NTR domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLM0

Conserved Domains (1) summary

cl02512
Location:4 → 36

NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...