htz-1 Histone H2A.V [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: htz-1
Gene description: Histone H2A.V
Primary source: WormBase:WBGene00019947
Locus tag: CELE_R08C7.3
See related: AllianceGenome:WB:WBGene00019947
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity. Involved in negative regulation of cell fate specification and negative regulation of transcription, DNA-templated. Located in chromatin; condensed chromosome; and nucleus. Is expressed in several structures, including somatic gonad. Orthologous to human H2AZ1 (H2A.Z variant histone 1) and H2AZ2 (H2A.Z variant histone 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 2

Sequence:: Chromosome: IV; NC_003282.8 (4446216..4446999)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HTZ-1 and MYS-1 repress ceh-22 when UTX-1 removes its silencing mark, H3K27 methylation on the ceh-22 locus, thereby maintaining the fates of SGCs.
Title: HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans.
Reducing levels of HTZ-1 leads to partial disruption of dosage compensation.
Title: Restricting dosage compensation complex binding to the X chromosomes by H2A.Z/HTZ-1.
HTZ-1 functions in establishing or maintaining an essential chromatin state at promoters regulated dynamically during C. elegans embryogenesis.
Title: The genomic distribution and function of histone variant HTZ-1 during C. elegans embryogenesis.
PHA-4 and HTZ-1 coordinate temporal gene expression by modulating the chromatin environment.
Title: Temporal regulation of foregut development by HTZ-1/H2A.Z and PHA-4/FoxA.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R08C7.3 (e-PCR)
- UniSTS:321020

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables nucleosomal DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of nucleosome	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Histone H2A.V

NP_500569.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

4446216..4446999

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068168.9 → NP_500569.1 Histone H2A.V [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500569.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27511

Conserved Domains (2) summary

PTZ00017
Location:3 → 135

PTZ00017; histone H2A; Provisional

cd00074
Location:10 → 124

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...