tald-1 Transaldolase [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: tald-1
Gene description: Transaldolase
Primary source: WormBase:WBGene00021286
Locus tag: CELE_Y24D9A.8
See related: AllianceGenome:WB:WBGene00021286
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable transaldolase activity. Predicted to be involved in pentose-phosphate shunt, non-oxidative branch. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder. Orthologous to human TALDO1 (transaldolase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 4

Sequence:: Chromosome: IV; NC_003282.8 (4386651..4388880)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lifespan extension from knockdown of tald-1 is associated with an oxidative stress response involving p38 and c-Jun N-terminal kinase (JNK) MAPKs and a starvation-like response regulated by the transcription factor EB (TFEB) homolog HLH-30. The latter response promotes autophagy and increases expression of the flavin-containing monooxygenase 2 (fmo-2)
Title: Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables transaldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transaldolase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt, non-oxidative branch	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in intracellular anatomical structure	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Transaldolase

NP_001367900.1

Confirmed by transcript evidence

NP_741369.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

4386651..4388880

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171314.7 → NP_741369.1 Transaldolase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741369.1

Status: REVIEWED

UniProtKB/TrEMBL

Q966C7

Conserved Domains (2) summary

PRK05269
Location:1 → 319

PRK05269; transaldolase B; Provisional

PTZ00411
Location:1 → 319

PTZ00411; transaldolase-like protein; Provisional
NM_001380188.1 → NP_001367900.1 Transaldolase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8T876

Conserved Domains (1) summary

cl21457
Location:1 → 165

TIM; TIM-like beta/alpha barrel domains