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rnp-3 RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177182, updated on 5-May-2024

Summary

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Gene symbol
rnp-3
Gene description
RRM domain-containing protein
Primary source
WormBase:WBGene00004386
Locus tag
CELE_K08D10.3
See related
AllianceGenome:WB:WBGene00004386
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable U1 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U1 snRNP. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to several human genes including SNRPA (small nuclear ribonucleoprotein polypeptide A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (4174089..4176279)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ShKT domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene J domain-containing protein Neighboring gene tRNA-intron lyase;tRNA_int_endo domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional redundancy of worm spliceosomal proteins U1A and U2B''. Saldi T, et al. Proc Natl Acad Sci U S A, 2007 Jun 5. PMID 17535930, Free PMC Article
  2. Spatial and temporal translational control of germ cell mRNAs mediated by the eIF4E isoform IFE-1. Friday AJ, et al. J Cell Sci, 2015 Dec 15. PMID 26542024
  3. Role of the C. elegans U2 snRNP protein MOG-2 in sex determination, meiosis, and splice site selection. Zanetti S, et al. Dev Biol, 2011 Jun 15. PMID 21504747
  4. Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons. Antonacci S, et al. G3 (Bethesda), 2015 Feb 10. PMID 25673135, Free PMC Article
  5. PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability. Cordeiro Rodrigues RJ, et al. Genes Dev, 2019 Jul 1. PMID 31147388, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables U1 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RRM domain-containing protein
NP_001294565.1
  • Confirmed by transcript evidence
NP_500505.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    4174089..4176279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068104.6 → NP_500505.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500505.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21323
    Conserved Domains (3) summary
    COG0724
    Location:6 → 177
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12246
    Location:9 → 86
    RRM1_U1A_like; RNA recognition motif 1 in the U1A/U2B"/SNF protein family
    cd12247
    Location:141 → 212
    RRM2_U1A_like; RNA recognition motif 2 in the U1A/U2B"/SNF protein family

  2. NM_001307636.3 → NP_001294565.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294565.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBX2
    Conserved Domains (3) summary
    COG0724
    Location:1 → 148
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12246
    Location:1 → 57
    RRM1_U1A_like; RNA recognition motif 1 in the U1A/U2B"/SNF protein family
    cd12247
    Location:112 → 183
    RRM2_U1A_like; RNA recognition motif 2 in the U1A/U2B"/SNF protein family
Nucleotide Protein
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