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cpsf-1 Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein;MMS1_N domain-containing protein;putative cleavage and polyadenylation specificity factor subunit 1 [ Caenorhabditis elegans ]

Gene ID: 177003, updated on 11-Apr-2024

Summary

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Gene symbol
cpsf-1
Gene description
Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein;MMS1_N domain-containing protein;putative cleavage and polyadenylation specificity factor subunit 1
Primary source
WormBase:WBGene00022301
Locus tag
CELE_Y76B12C.7
See related
AllianceGenome:WB:WBGene00022301
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA polyadenylation. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myopia. Orthologous to human CPSF1 (cleavage and polyadenylation specific factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
16
Sequence:
Chromosome: IV; NC_003282.8 (2009038..2032996, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene TPR_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene XPC (Xeroderma Pigmentosum group C) DNA repair gene homolog Neighboring gene NUP50 domain-containing protein Neighboring gene Cyclic nucleotide-binding domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Different Mi-2 complexes for various developmental functions in Caenorhabditis elegans. Passannante M, et al. PLoS One, 2010 Oct 27. PMID 21060680, Free PMC Article
  2. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
  3. The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling. Rüegger S, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25753661, Free PMC Article
  4. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
  5. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein;MMS1_N domain-containing protein;putative cleavage and polyadenylation specificity factor subunit 1
NP_001368311.1
  • Confirmed by transcript evidence
NP_001368312.1
  • Confirmed by transcript evidence
NP_001368313.1
  • Confirmed by transcript evidence
NP_500157.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    2009038..2032996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067756.6 → NP_500157.2  putative cleavage and polyadenylation specificity factor subunit 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500157.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N4C2
    Conserved Domains (3) summary
    COG5161
    Location:10 → 1447
    SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]
    pfam03178
    Location:1079 → 1420
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:93 → 623
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term

  2. NM_001380077.1 → NP_001368311.1  MMS1_N domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PCC4
    Conserved Domains (2) summary
    COG5161
    Location:1 → 1256
    SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]
    pfam03178
    Location:888 → 1229
    CPSF_A; CPSF A subunit region

  3. NM_001380079.1 → NP_001368312.1  Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PMR4
    Conserved Domains (1) summary
    pfam03178
    Location:2 → 318
    CPSF_A; CPSF A subunit region

  4. NM_001380080.1 → NP_001368313.1  Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PS25
    Conserved Domains (1) summary
    pfam03178
    Location:3 → 77
    CPSF_A; CPSF A subunit region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N4C2.2

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