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rbm-39 RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176922, updated on 3-Mar-2024

Summary

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Gene symbol
rbm-39
Gene description
RRM domain-containing protein
Primary source
WormBase:WBGene00021921
Locus tag
CELE_Y55F3AM.3
See related
AllianceGenome:WB:WBGene00021921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chromatin DNA binding activity. Predicted to be involved in nuclear envelope organization. Predicted to be located in nucleus. Predicted to be integral component of nuclear inner membrane. Is expressed in neurons; pharynx; and tail. Orthologous to several human genes including RBM39 (RNA binding motif protein 39). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (1012624..1019558)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ubiquitin carboxyl-terminal hydrolase Neighboring gene Ubiquitin-like-conjugating enzyme ATG3 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC. Kang YK, et al. PLoS Genet, 2015 Apr. PMID 25830341, Free PMC Article
  2. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear envelope organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RRM domain-containing protein
NP_001380075.1
  • Confirmed by transcript evidence
NP_500025.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1012624..1019558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392253.1 → NP_001380075.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MXS6
    Conserved Domains (1) summary
    TIGR01622
    Location:5 → 370
    SF-CC1; splicing factor, CC1-like family

  2. NM_067624.5 → NP_500025.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500025.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N368
    Conserved Domains (4) summary
    cd12283
    Location:171 → 243
    RRM1_RBM39_like; RNA recognition motif 1 in vertebrate RNA-binding protein 39 (RBM39) and similar proteins
    cd12285
    Location:421 → 505
    RRM3_RBM39_like; RNA recognition motif 3 in vertebrate RNA-binding protein 39 (RBM39) and similar proteins
    pfam15519
    Location:367 → 438
    RBM39linker; linker between RRM2 and RRM3 domains in RBM39 protein
    cl17169
    Location:276 → 345
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. NR_136395.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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