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Msi1 musashi RNA-binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 17690, updated on 16-Apr-2024

Summary

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Official Symbol
Msi1provided by MGI
Official Full Name
musashi RNA-binding protein 1provided by MGI
Primary source
MGI:MGI:107376
See related
Ensembl:ENSMUSG00000054256 AllianceGenome:MGI:107376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msi1h; Musahi1; m-Msi-1
Summary
Enables identical protein binding activity and poly(U) RNA binding activity. Predicted to be involved in response to hormone. Located in cytoplasm and nucleus. Part of polysome. Is expressed in central nervous system; gut; ovary; sensory organ; and skin. Orthologous to human MSI1 (musashi RNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 68.1), whole brain E14.5 (RPKM 37.5) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 56.09 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115567734..115593757)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115359059..115455698)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930401G09 gene Neighboring gene predicted gene 13832 Neighboring gene STARR-seq mESC enhancer starr_14119 Neighboring gene RIKEN cDNA A930005G22 gene Neighboring gene phospholipase A2, group IB, pancreas Neighboring gene STARR-seq mESC enhancer starr_14129 Neighboring gene sirtuin 4 Neighboring gene predicted gene, 42007

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma. Kameda-Smith MM, et al. Nat Commun, 2022 Dec 6. PMID 36473869, Free PMC Article
  2. Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3-Mmp9 pathway. Bi X, et al. Oncogene, 2021 Jul. PMID 34155343
  3. Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA. Iwaoka R, et al. Molecules, 2017 Jul 19. PMID 28753936, Free PMC Article
  4. RNA-binding Protein Musashi Homologue 1 Regulates Kidney Fibrosis by Translational Inhibition of p21 and Numb mRNA. Jadhav S, et al. J Biol Chem, 2016 Jul 1. PMID 27129280, Free PMC Article
  5. A Mouse Model of Targeted Musashi1 Expression in Whole Intestinal Epithelium Suggests Regulatory Roles in Cell Cycle and Stemness. Cambuli FM, et al. Stem Cells, 2015 Dec. PMID 26303183, Free PMC Article

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells.
    Title: Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells.
  2. MSI1 Stabilizes MACF1 to Inhibit Apoptosis of MC3T3-E1 Cells Induced by High Glucose and Promote Osteogenic Differentiation Through Wnt/beta-Catenin Signaling Pathway.
    Title: MSI1 Stabilizes MACF1 to Inhibit Apoptosis of MC3T3-E1 Cells Induced by High Glucose and Promote Osteogenic Differentiation Through Wnt/β-Catenin Signaling Pathway.
  3. Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue.
    Title: Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue.
  4. Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi.
    Title: Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi.
  5. Constitutive Musashi1 expression impairs mouse postnatal development and intestinal homeostasis.
    Title: Constitutive Musashi1 expression impairs mouse postnatal development and intestinal homeostasis.
  6. The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice.
    Title: The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice.
  7. Interplay among p21(Waf1/Cip1), MUSASHI-1 and Kruppel-like factor 4 in activation of Bmi1-Cre(ER) reserve intestinal stem cells after gamma radiation-induced injury.
    Title: Interplay among p21(Waf1/Cip1), MUSASHI-1 and Krüppel-like factor 4 in activation of Bmi1-Cre(ER) reserve intestinal stem cells after gamma radiation-induced injury.
  8. Msi1 has two RNA-binding domains.
    Title: Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA.
  9. leptin's direct stimulatory actions on gonadotrope GnRHR correlate with a direct inhibition of expression of the posttranscriptional regulator MSI1. There also is a direct MSI1 interaction with 3'-UTR of Gnrhr mRNA.
    Title: Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression.
  10. Msi proteins are dispensable for normal homeostasis and self-renewal of the active intestinal stem cell.
    Title: Msi RNA-binding proteins control reserve intestinal stem cell quiescence.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RNA-binding protein Musashi homolog 1
Names
Musashi homolog 1(Drosophila)
musashi-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376960.1 → NP_001363889.1  RNA-binding protein Musashi homolog 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117735
    UniProtKB/TrEMBL
    F8WJA5
    Conserved Domains (3) summary
    TIGR01628
    Location:32 → 328
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110 → 183
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:22 → 96
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

  2. NM_001376961.1 → NP_001363890.1  RNA-binding protein Musashi homolog 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117735
    UniProtKB/TrEMBL
    F8WJA5
    Conserved Domains (3) summary
    TIGR01628
    Location:32 → 320
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110 → 183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:21 → 96
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

  3. NM_001376962.1 → NP_001363891.1  RNA-binding protein Musashi homolog 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC117735
    UniProtKB/TrEMBL
    F8WJA5
    Conserved Domains (3) summary
    TIGR01628
    Location:32 → 329
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110 → 183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:21 → 96
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

  4. NM_001376963.1 → NP_001363892.1  RNA-binding protein Musashi homolog 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC117735
    Conserved Domains (2) summary
    TIGR01628
    Location:2 → 174
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:1 → 45
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. NM_001417504.1 → NP_001404433.1  RNA-binding protein Musashi homolog 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC117735
    Related
    ENSMUSP00000070415.6, ENSMUST00000067168.9

  6. NM_001417505.1 → NP_001404434.1  RNA-binding protein Musashi homolog 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC117735

  7. NM_001417506.1 → NP_001404435.1  RNA-binding protein Musashi homolog 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC117735

  8. NM_001417507.1 → NP_001404436.1  RNA-binding protein Musashi homolog 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC117735

  9. NM_001417508.1 → NP_001404437.1  RNA-binding protein Musashi homolog 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC117735

  10. NM_001417509.1 → NP_001404438.1  RNA-binding protein Musashi homolog 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC117735
    Related
    ENSMUSP00000144032.2, ENSMUST00000131079.8

  11. NM_001417510.1 → NP_001404439.1  RNA-binding protein Musashi homolog 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC117735

  12. NM_001417511.1 → NP_001404440.1  RNA-binding protein Musashi homolog 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC117735

  13. NM_001417512.1 → NP_001404441.1  RNA-binding protein Musashi homolog 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC117735
    Related
    ENSMUSP00000143900.2, ENSMUST00000136586.6

  14. NM_001417513.1 → NP_001404442.1  RNA-binding protein Musashi homolog 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC117735

  15. NM_001417514.1 → NP_001404443.1  RNA-binding protein Musashi homolog 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC117735

  16. NM_001417515.1 → NP_001404444.1  RNA-binding protein Musashi homolog 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC117735

  17. NM_001417516.1 → NP_001404445.1  RNA-binding protein Musashi homolog 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC117735

  18. NM_001417517.1 → NP_001404446.1  RNA-binding protein Musashi homolog 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC117735

  19. NM_001417518.1 → NP_001404447.1  RNA-binding protein Musashi homolog 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC117735

  20. NM_008629.2 → NP_032655.1  RNA-binding protein Musashi homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_032655.1

    Status: VALIDATED

    Source sequence(s)
    AC117735
    Consensus CDS
    CCDS19591.1
    UniProtKB/Swiss-Prot
    Q61474, Q8BNC7
    UniProtKB/TrEMBL
    F8WJA5
    Related
    ENSMUSP00000120516.2, ENSMUST00000150779.8
    Conserved Domains (3) summary
    TIGR01628
    Location:32 → 312
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110 → 183
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:22 → 96
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115567734..115593757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530181.5 → XP_006530244.1  RNA-binding protein Musashi homolog 1 isoform X1

    Conserved Domains (2) summary
    TIGR01628
    Location:8 → 209
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:7 → 80
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

  2. XM_036164849.1 → XP_036020742.1  RNA-binding protein Musashi homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A0J9YTX9
    Conserved Domains (2) summary
    TIGR01628
    Location:8 → 226
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:7 → 80
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

  3. XM_030254188.1 → XP_030110048.1  RNA-binding protein Musashi homolog 1 isoform X4

    Conserved Domains (2) summary
    TIGR01628
    Location:2 → 190
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:1 → 45
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_036164850.1 → XP_036020743.1  RNA-binding protein Musashi homolog 1 isoform X4

    Conserved Domains (2) summary
    TIGR01628
    Location:2 → 190
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:1 → 45
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. XM_036164852.1 → XP_036020745.1  RNA-binding protein Musashi homolog 1 isoform X6

    Conserved Domains (2) summary
    TIGR01628
    Location:2 → 191
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:1 → 45
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61474.1 GenPept UniProtKB/Swiss-Prot:Q61474

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