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ubq-2 Ubiquitin [ Caenorhabditis elegans ]

Gene ID: 176718, updated on 25-Apr-2024

Summary

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Gene symbol
ubq-2
Gene description
Ubiquitin
Primary source
WormBase:WBGene00006728
Locus tag
CELE_ZK1010.1
See related
AllianceGenome:WB:WBGene00006728
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tag and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Involved in polarity specification of anterior/posterior axis. Predicted to be located in ribosome. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including hermaphrodite gonad; intestine; pharyngeal-intestinal valve; pharynx; and somatic nervous system. Orthologous to human UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (12977963..12978523, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene 2-oxoisovalerate dehydrogenase subunit alpha;2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial Neighboring gene DUF155 domain-containing protein Neighboring gene Protein FRG1 homolog Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Screening and analysis of Hc-ubq and Hc-gst related to desiccation survival of infective Haemonchus contortus larvae. Yang Y, et al. Vet Parasitol, 2015 Jun 15. PMID 25913452
  2. A portable regulatory element directs specific expression of the Caenorhabditis elegans ubiquitin gene ubq-2 in the somatic gonad. Jones D, et al. Dev Biol, 1995 Sep. PMID 7556908
  3. The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation. Rappleye CA, et al. Dev Cell, 2002 Feb. PMID 11832245
  4. Anaphase-promoting complex in Caenorhabditis elegans. Yeong FM. Mol Cell Biol, 2004 Mar. PMID 14993261, Free PMC Article
  5. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Gönczy P, et al. Nature, 2000 Nov 16. PMID 11099034

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in polarity specification of anterior/posterior axis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ubiquitin
NP_499695.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12977963..12978523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067294.6 → NP_499695.1  Ubiquitin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499695.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P14792, P49632, Q9U1P3
    Conserved Domains (3) summary
    cd01803
    Location:1 → 76
    Ubiquitin; Ubiquitin
    smart00213
    Location:1 → 72
    UBQ; Ubiquitin homologues
    pfam01020
    Location:78 → 126
    Ribosomal_L40e; Ribosomal L40e family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49632.2

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