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rsp-3 putative splicing factor, arginine/serine-rich 3 [ Caenorhabditis elegans ]

Gene ID: 176688, updated on 5-May-2024

Summary

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Gene symbol
rsp-3
Gene description
putative splicing factor, arginine/serine-rich 3
Primary source
WormBase:WBGene00004700
Locus tag
CELE_Y111B2A.18
See related
AllianceGenome:WB:WBGene00004700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Involved in embryo development. Predicted to be located in nucleus. Predicted to be active in nuclear speck. Is expressed in body wall musculature; gonad; nervous system; and pharynx. Orthologous to several human genes including SRSF9 (serine and arginine rich splicing factor 9). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (12686701..12687916, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene TAFII55 protein conserved region domain-containing protein Neighboring gene Elongator complex protein 2 Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple interactions between SRm160 and SR family proteins in enhancer-dependent splicing and development of C. elegans. Longman D, et al. Curr Biol, 2001 Dec 11. PMID 11747818
  2. Mass spectrometric proteome analysis suggests anaerobic shift in metabolism of Dauer larvae of Caenorhabditis elegans. Mádi A, et al. Biochim Biophys Acta, 2008 Nov. PMID 18620082
  3. SPK-1, a C. elegans SR protein kinase homologue, is essential for embryogenesis and required for germline development. Kuroyanagi H, et al. Mech Dev, 2000 Dec. PMID 11091073
  4. Profiling stage-dependent changes of protein expression in Caenorhabditis elegans by mass spectrometric proteome analysis leads to the identification of stage-specific marker proteins. Mádi A, et al. Electrophoresis, 2003 Jun. PMID 12783458
  5. Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Longman D, et al. Genes Dev, 2007 May 1. PMID 17437990, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splice site recognition ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative splicing factor, arginine/serine-rich 3
NP_001370111.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12686701..12687916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383015.1 → NP_001370111.1  putative splicing factor, arginine/serine-rich 3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9GQI7, Q9NEW6
    Conserved Domains (2) summary
    cd12338
    Location:10 → 80
    RRM1_SRSF1_like; RNA recognition motif 1 (RRM1) found in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins
    cd12601
    Location:123 → 196
    RRM2_SRSF1_like; RNA recognition motif 2 (RRM2) found in serine/arginine-rich splicing factor SRSF1, SRSF9 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NEW6.2

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