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psme-3 Proteasome activator PA28 C-terminal domain-containing protein;Proteasome activator complex subunit 3 [ Caenorhabditis elegans ]

Gene ID: 176588, updated on 5-May-2024

Summary

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Gene symbol
psme-3
Gene description
Proteasome activator PA28 C-terminal domain-containing protein;Proteasome activator complex subunit 3
Primary source
WormBase:WBGene00013435
Locus tag
CELE_Y66D12A.9
See related
AllianceGenome:WB:WBGene00013435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable endopeptidase activator activity. Predicted to be involved in positive regulation of endopeptidase activity; regulation of G1/S transition of mitotic cell cycle; and regulation of proteasomal protein catabolic process. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human PSME3 (proteasome activator subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (11568137..11573343)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Pollen-specific leucine-rich repeat extensin-like protein 1 Neighboring gene ncRNA Neighboring gene MITD1 C-terminal phospholipase D-like domain-containing protein Neighboring gene STING ER exit protein Neighboring gene Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes. Lee HJ, et al. Nat Aging, 2023 May. PMID 37118550, Free PMC Article
  2. DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Lin XX, et al. Nat Commun, 2018 Oct 23. PMID 30353013, Free PMC Article
  3. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cold temperature extends longevity and prevents disease-related protein aggregation through PA28gamma-induced proteasomes.
    Title: Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables endopeptidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome activator complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Proteasome activator PA28 C-terminal domain-containing protein;Proteasome activator complex subunit 3
NP_001407530.1
  • Confirmed by transcript evidence
NP_499493.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11568137..11573343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067092.8 → NP_499493.1  Proteasome activator complex subunit 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499493.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95PZ7
    Conserved Domains (2) summary
    pfam02251
    Location:11 → 68
    PA28_alpha; Proteasome activator pa28 alpha subunit
    pfam02252
    Location:105 → 246
    PA28_beta; Proteasome activator pa28 beta subunit

  2. NM_001420556.1 → NP_001407530.1  Proteasome activator PA28 C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4SQL6
Nucleotide Protein
Heading Accession and Version

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