mcm-10 Protein MCM10 homolog [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: mcm-10
Gene description: Protein MCM10 homolog
Primary source: WormBase:WBGene00012935
Locus tag: CELE_Y47D3A.28
See related: AllianceGenome:WB:WBGene00012935
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA replication origin binding activity and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation. Predicted to be located in nucleus. Predicted to be part of replication fork protection complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCM10 (minichromosome maintenance 10 replication initiation factor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: III

Exon count:: 14

Sequence:: Chromosome: III; NC_003281.10 (11317570..11326664)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y47D3A.ee (e-PCR)
- UniSTS:324079

Y47D3A.ff (e-PCR)
- UniSTS:324345

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nuclear replication fork	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein MCM10 homolog

NP_499456.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

11317570..11326664

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067055.4 → NP_499456.1 Protein MCM10 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499456.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U2C2

Conserved Domains (2) summary

pfam09329
Location:258 → 304

zf-primase; Primase zinc finger

pfam09332
Location:365 → 691

Mcm10; Mcm10 replication factor