U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

teg-1 GYF domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176561, updated on 23-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
teg-1
Gene description
GYF domain-containing protein
Primary source
WormBase:WBGene00006563
Locus tag
CELE_Y47D3A.27
See related
AllianceGenome:WB:WBGene00006563
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in positive regulation of production of miRNAs involved in gene silencing by miRNA and positive regulation of stem cell differentiation. Located in cytoplasm and nucleoplasm. Is expressed in seam cell; uterus; and vulva. Orthologous to human CD2BP2 (CD2 cytoplasmic tail binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (11312229..11317055, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Structural maintenance of chromosomes protein 3 Neighboring gene Ras-related protein Rab-35 Neighboring gene Protein MCM10 homolog Neighboring gene GTP-binding protein 128up;OBG-type G domain-containing protein Neighboring gene CUB domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells. Wang C, et al. Nucleic Acids Res, 2017 Feb 17. PMID 28180320, Free PMC Article
  2. TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor. Wang C, et al. Dev Dyn, 2012 Mar. PMID 22275078, Free PMC Article
  3. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Crawford ED, et al. Cell Death Differ, 2012 Dec. PMID 22918439, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TEG-1 regulates the stability of two miRISC effectors, VIG-1 and ALG-1, which in turn affects the abundance of miRNAs in various families.
    Title: TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells.
  2. TEG-1 functions as a splicing factor and acts to regulate the proliferation versus meiosis decision.
    Title: TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of miRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stem cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U5 snRNP IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
GYF domain-containing protein
NP_499455.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11312229..11317055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067054.8 → NP_499455.2  GYF domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499455.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NAH3
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous