orc-1 Origin recognition complex subunit 1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: orc-1
Gene description: Origin recognition complex subunit 1
Primary source: WormBase:WBGene00012650
Locus tag: CELE_Y39A1A.12
See related: AllianceGenome:WB:WBGene00012650
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication initiation and mitotic DNA replication checkpoint signaling. Predicted to be located in nucleus. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in germ line. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (10643129..10646058)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y39A1A.12 (e-PCR)
- UniSTS:312849

Y39A1A.13 (e-PCR)
- UniSTS:313305

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of nuclear origin of replication recognition complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Origin recognition complex subunit 1

NP_499347.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10643129..10646058

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066946.7 → NP_499347.1 Origin recognition complex subunit 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499347.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XX17

Conserved Domains (3) summary

smart01074
Location:542 → 623

Cdc6_C; CDC6, C terminal

PRK00411
Location:263 → 630

cdc6; cell division control protein 6; Reviewed

pfam00004
Location:295 → 447

AAA; ATPase family associated with various cellular activities (AAA)