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div-1 DNA polymerase alpha subunit B [ Caenorhabditis elegans ]

Gene ID: 176439, updated on 25-Apr-2024

Summary

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Gene symbol
div-1
Gene description
DNA polymerase alpha subunit B
Primary source
WormBase:WBGene00001002
Locus tag
CELE_R01H10.1
See related
AllianceGenome:WB:WBGene00001002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity. Predicted to be involved in DNA replication initiation. Predicted to be located in nucleus. Predicted to be part of alpha DNA polymerase:primase complex. Is expressed in gonad; pharynx; vulva; and vulval precursor cell. Orthologous to human POLA2 (DNA polymerase alpha 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (10245056..10248559, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene EGF-like domain-containing protein Neighboring gene Solute carrier organic anion transporter family member Neighboring gene ncRNA Neighboring gene Coronin-like protein cor-1 Neighboring gene Uncharacterized protein Neighboring gene RFS-1 Interacting Partner

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint. Lee SJ, et al. Development, 2004 Jun. PMID 15115755
  2. Reproductive isolation in Caenorhabditis: terminal phenotypes of hybrid embryos. Baird SE, et al. Evol Dev, 2000 Jan-Feb. PMID 11256419
  3. Onset of C. elegans gastrulation is blocked by inhibition of embryonic transcription with an RNA polymerase antisense RNA. Powell-Coffman JA, et al. Dev Biol, 1996 Sep 15. PMID 8812143
  4. Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline. Yoon DS, et al. FEBS J, 2018 Jul. PMID 29775245, Free PMC Article
  5. emb-5, a gene required for the correct timing of gut precursor cell division during gastrulation in Caenorhabditis elegans, encodes a protein similar to the yeast nuclear protein SPT6. Nishiwaki K, et al. Mol Gen Genet, 1993 Jun. PMID 8391108

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA polymerase alpha subunit B
NP_499268.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10245056..10248559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066867.6 → NP_499268.1  DNA polymerase alpha subunit B [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499268.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21625
    Conserved Domains (1) summary
    pfam04042
    Location:324 → 531
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21625.3

Gene LinkOut

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