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spop-1 Speckle-type POZ protein homolog [ Caenorhabditis elegans ]

Gene ID: 176422, updated on 25-Apr-2024

Summary

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Gene symbol
spop-1
Gene description
Speckle-type POZ protein homolog
Primary source
WormBase:WBGene00011815
Locus tag
CELE_T16H12.5
See related
AllianceGenome:WB:WBGene00011815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be active in cytoplasm and nucleus. Orthologous to several human genes including SPOPL (speckle type BTB/POZ protein like). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (10090862..10098081, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Coiled-coil domain-containing protein Neighboring gene General transcription factor IIH subunit 2 Neighboring gene Kelch repeat-containing protein kel-10 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deficiency of cardiolipin synthase causes abnormal mitochondrial function and morphology in germ cells of Caenorhabditis elegans. Sakamoto T, et al. J Biol Chem, 2012 Feb 10. PMID 22174409, Free PMC Article
  2. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Speckle-type POZ protein homolog
NP_001022764.1
  • Confirmed by transcript evidence
NP_001022765.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10090862..10098081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027593.2 → NP_001022764.1  Speckle-type POZ protein homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022764.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34568, Q5CZ49
    Conserved Domains (4) summary
    smart00225
    Location:266 → 368
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd03774
    Location:92 → 230
    MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
    cd14734
    Location:368 → 430
    SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00651
    Location:255 → 365
    BTB; BTB/POZ domain

  2. NM_001027594.6 → NP_001022765.1  Speckle-type POZ protein homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022765.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34568
    Conserved Domains (4) summary
    smart00225
    Location:224 → 326
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd03774
    Location:50 → 188
    MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
    cd14734
    Location:326 → 388
    SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00651
    Location:213 → 323
    BTB; BTB/POZ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34568.2

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