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gpdh-2 Glycerol-3-phosphate dehydrogenase [NAD(+)];putative glycerol-3-phosphate dehydrogenase 2 [ Caenorhabditis elegans ]

Gene ID: 176399, updated on 11-Apr-2024

Summary

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Gene symbol
gpdh-2
Gene description
Glycerol-3-phosphate dehydrogenase [NAD(+)];putative glycerol-3-phosphate dehydrogenase 2
Primary source
WormBase:WBGene00010778
Locus tag
CELE_K11H3.1
See related
AllianceGenome:WB:WBGene00010778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glycerol-3-phosphate dehydrogenase (quinone) activity and glycerol-3-phosphate dehydrogenase [NAD+] activity. Involved in intracellular accumulation of glycerol. Predicted to be located in cytoplasm. Predicted to be part of glycerol-3-phosphate dehydrogenase complex. Predicted to be active in cytosol. Is expressed in several structures, including body wall musculature; excretory cell; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1) and GPD1L (glycerol-3-phosphate dehydrogenase 1 like). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (9854074..9859183, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative tricarboxylate transport protein, mitochondrial Neighboring gene Potassium channel domain-containing protein Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ser

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inheritance of protection from osmotic stress. Kaneshiro KR, et al. Nat Cell Biol, 2017 Mar 1. PMID 28248305
  2. Insulin-like signalling to the maternal germline controls progeny response to osmotic stress. Burton NO, et al. Nat Cell Biol, 2017 Mar. PMID 28166192, Free PMC Article
  3. Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stress. Lamitina ST, et al. Am J Physiol Cell Physiol, 2004 Apr. PMID 14644776
  4. FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores. Possik E, et al. PLoS Genet, 2015 Oct. PMID 26439621, Free PMC Article
  5. Genetic and physiological activation of osmosensitive gene expression mimics transcriptional signatures of pathogen infection in C. elegans. Rohlfing AK, et al. PLoS One, 2010 Feb 2. PMID 20126308, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate dehydrogenase (quinone) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADH oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol-3-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hyperosmotic response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular accumulation of glycerol IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycerol-3-phosphate dehydrogenase (FAD) complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Glycerol-3-phosphate dehydrogenase [NAD(+)];putative glycerol-3-phosphate dehydrogenase 2
NP_001122709.1
  • Confirmed by transcript evidence
NP_001122710.1
  • Confirmed by transcript evidence
NP_499188.2
  • Confirmed by transcript evidence
NP_871632.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9854074..9859183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066787.7 → NP_499188.2  Glycerol-3-phosphate dehydrogenase [NAD(+)] [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499188.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JMU1
    Conserved Domains (3) summary
    TIGR03376
    Location:25 → 364
    glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
    pfam01210
    Location:25 → 196
    NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
    pfam07479
    Location:219 → 357
    NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

  2. NM_181903.7 → NP_871632.1  putative glycerol-3-phosphate dehydrogenase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871632.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34517, Q8I4H2
    Conserved Domains (3) summary
    TIGR03376
    Location:37 → 385
    glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
    pfam01210
    Location:37 → 217
    NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
    pfam07479
    Location:240 → 378
    NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

  3. NM_001129237.4 → NP_001122709.1  Glycerol-3-phosphate dehydrogenase [NAD(+)] [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122709.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7LPE5
    Conserved Domains (3) summary
    TIGR03376
    Location:5 → 297
    glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
    pfam07479
    Location:152 → 290
    NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
    cl21454
    Location:5 → 129
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. NM_001129238.4 → NP_001122710.1  Glycerol-3-phosphate dehydrogenase [NAD(+)] [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122710.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7LPE6
    Conserved Domains (3) summary
    TIGR03376
    Location:5 → 353
    glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
    pfam01210
    Location:5 → 185
    NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
    pfam07479
    Location:208 → 346
    NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34517.2

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