pri-1 DNA primase small subunit [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: pri-1
Gene description: DNA primase small subunit
Primary source: WormBase:WBGene00004180
Locus tag: CELE_F58A4.4
See related: AllianceGenome:WB:WBGene00004180
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA primase activity. Predicted to be involved in DNA replication, synthesis of RNA primer. Predicted to be part of alpha DNA polymerase:primase complex. Orthologous to human PRIM1 (DNA primase subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (9612254..9614281, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The findings suggest that the subunits of the DNA polymerase alpha-primase complex exhibit both discrete and shared functions in GLP-1/Notch or PUF-mediated germ cell dynamics in C. elegans.
Title: Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F58A4.6 (e-PCR)
- UniSTS:320734

F58A4.4 (e-PCR)
- UniSTS:321525

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA primase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA primase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication, synthesis of primer	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication, synthesis of primer	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated DNA replication	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of alpha DNA polymerase:primase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA primase small subunit

NP_001255015.1

Confirmed by transcript evidence

NP_001255016.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9612254..9614281 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268086.2 → NP_001255015.1 DNA primase small subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255015.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34471

Conserved Domains (1) summary

cd04860
Location:21 → 352

AE_Prim_S; AE_Prim_S: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. Primases are DNA-dependent RNA polymerases which synthesis the short RNA primers required for DNA replication. In addition to its ...
NM_001268087.3 → NP_001255016.1 DNA primase small subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255016.1

Status: REVIEWED

UniProtKB/TrEMBL

G3MTW9

Conserved Domains (1) summary

cl01287
Location:20 → 59

AE_Prim_S_like; AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis ...